Evidence map›Paper›PMID 41823551›Full record

ArticleInternational journal of molecular medicine2026

4‑Acetylantrocamol LT3 suppresses colorectal cancer growth and metastasis via PI3K/AKT and MAPK pathway modulation.

Kuen-Tze Lin, Yu-Chieh Hsieh, Pi-Kai Chang, Chih-Wei Lai, Shih-Yu Lee, I-Chuan Yen

Abstract read
In one paragraph

Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kuen-Tze LinDepartment of Radiation Oncology, Cardinal Tien Hospital, New Taipei City 23148, Taiwan, R.O.C.
Yu-Chieh HsiehSchool of Pharmacy, National Defense Medical University, Taipei City 11490, Taiwan, R.O.C.
Pi-Kai ChangSchool of Medicine, National Defense Medical University, Taipei City 11490, Taiwan, R.O.C.
Chih-Wei LaiSchool of Pharmacy, National Defense Medical University, Taipei City 11490, Taiwan, R.O.C.
Shih-Yu LeeDepartment of Radiology, Taoyuan Armed Forces General Hospital, Taoyuan 325208, Taiwan, R.O.C.
I-Chuan YenSchool of Pharmacy, National Defense Medical University, Taipei City 11490, Taiwan, R.O.C.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) remains one of the leading causes of cancer‑related mortality worldwide. Despite advances in targeted therapies, drug resistance and limited efficacy in KRAS‑mutant CRC continue to present clinical challenges.

Indexed as

Colorectal NeoplasmsMAP Kinase Signaling SystemPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHCT116 CellsHumansMolecular Docking SimulationNeoplasm MetastasisProtein Interaction MapsSignal TransductionPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-akt4‑acetylantrocamol LT3Antrodia cinnamomeacolorectal cancerCyclin D1molecular dockingPI3K/AKT/mTORRNA sequencingsolute carrier family 3 member 2

Identifiers

PMID41823551
PMCPMC13007996

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.