ArticleInternational journal of molecular medicine2026
HELLS inhibits autophagy‑dependent ferroptosis in nasopharyngeal carcinoma by modulating the Nrf2/HO‑1/GPX4 pathway.
Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
The present study aimed to elucidate the role of lymphoid‑specific helicase (HELLS) in autophagy‑dependent ferroptosis in nasopharyngeal carcinoma (NPC) cells and associated mechanisms. Bioinformatics analyses were conducted to identify the key gene. Gene knockout was accomplished through short‑hairpin RNA transfection. Reverse transcription‑quantitative polymerase chain reaction was conducted to evaluate mRNA expression, whereas protein expression was assessed through immunohistochemistry and western blotting. Furthermore, cell proliferation, migration, invasion and apoptosis were investigated via the Cell Counting Kit‑8, Transwell and flow cytometry assays. Glutathione (GSH), malondialdehyde (MDA) and Fe
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