Evidence map›Paper›PMID 41823527›Full record

ArticleOncology reports2026

Unveiling the role of ANGPT2 in esophageal cancer: A prognostic factor and potential oncogene.

Zhigang Zhai, Zhenyu Xue, Yuan Fang, Yixu Fan, Shijiao Li, Yunpeng Yu, Chuansheng Chen, Kaijun Zhang, Deyu Chen, Xiang Tang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhigang Zhai *Thoracic Oncology Department, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China.
Zhenyu Xue *Head and Neck Oncology Department, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China.
Yuan Fang *Abdominal Oncology Department, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China.
Yixu FanAbdominal Oncology Department, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China.
Shijiao LiAbdominal Oncology Department, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China.
Yunpeng YuThoracic Oncology Department, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China.
Chuansheng ChenAbdominal Oncology Department, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China.
Kaijun ZhangAbdominal Oncology Department, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China.
Deyu ChenHead and Neck Oncology Department, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China.
Xiang TangAbdominal Oncology Department, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China.
Rui LingThoracic Oncology Department, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal cancer (ESCA) is defined by high incidence and mortality rates. Emerging evidence implicates angiopoietin‑2 (ANGPT2) as a key mediator in human carcinogenesis; however, its precise functional role and underlying mechanisms in ESCA remain incompletely elucidated. Clinical samples and The Cancer Genome Atlas, genotype‑tissue expression and Gene Expression Omnibus databases were first used to analyze ANGPT2 expression, clinical relevance and prognostic value, demonstrating it as an independent prognostic factor and potential oncogene in ESCA. In addition, abnormal ANGPT2 expression affected ESCA migration and invasion

Indexed as

Angiopoietin-2Biomarkers, TumorEsophageal NeoplasmsCell MovementFemaleGene Expression Regulation, NeoplasticHumansMaleMicroRNAsOncogenesPrognosisTumor MicroenvironmentAngiopoietin-2ANGPT2 protein, humanBiomarkers, TumorMicroRNAsangiopoietin‑2biomarkeresophageal cancerimmunityprognosis

Identifiers

PMID41823527
PMCPMC13007277

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.