Evidence map›Paper›PMID 41823424›Full record

ReviewThe Journal of clinical endocrinology and metabolism2026

Approach to the patient with severe hyperthyroidism-related complications.

Georgios Kostopoulos, Grigoris Effraimidis

Abstract readReview
In one paragraph

Review in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Georgios KostopoulosDepartment of Endocrinology and Metabolism, Hippokration General Hospital, 54642 Thessaloniki, Greece.ORCID 0000-0003-1081-334X
Grigoris EffraimidisFaculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece.ORCID 0000-0001-7313-8391

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperthyroidism is a prevalent endocrine disorder that can lead to severe multisystem complications, including atrial fibrillation (AF), thyrotoxic periodic paralysis (TPP), and thyroid storm (TS). This review discusses the pathophysiology, clinical presentation, and management challenges of these complications through illustrative clinical cases. AF is the most common cardiovascular manifestation, with restoration of euthyroidism and rate control being central to treatment. TPP presents with transient muscle weakness due to hypokalemia from intracellular potassium shift, requiring cautious potassium supplementation and hyperthyroidism control. TS is a life-threatening endocrine emergency characterized by multisystem decompensation, necessitating prompt multimodal therapy including antithyroid drugs, beta-blockers, corticosteroids, and supportive care. Thus, early recognition and tailored management remain the cornerstones of successful treatment for these severe complications of hyperthyroidism.

Indexed as

Atrial FibrillationHyperthyroidismThyroid CrisisAntithyroid AgentsHumansThyrotoxicosisAntithyroid Agentsatrial fibrillationcomplicationshyperthyroidismthyrotoxicosisthyrotoxic periodic paralysisthyrotoxic storm

Identifiers

PMID41823424
PMCPMC13502199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.