Evidence map›Paper›PMID 41823358›Full record

ArticleActa physiologica (Oxford, England)2026

Sex Differences in the Effects of Etonogestrel on Respiratory Recovery in an In Vivo Rat Model of Central Chemoreflex Impairment.

Silvia Cardani, Tara A Janes, Ryaad Asif, Silvia Pagliardini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Silvia CardaniDepartment of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Tara A JanesDepartment of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0002-2824-9487
Ryaad AsifDepartment of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Silvia PagliardiniDepartment of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0002-1482-9173

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Canadian Institute for Health Research (CIHR) Postdoctoral FellowshipsCanadian Lung Association BaO FellowshipCIHR Project scheme #486764NIH HHS P51 OD011092Oregon National Primate Research CenterOrganon Investigator-Initiated Study Program #55869University of Alberta
6 · The paper itself

Abstract

aimRhythmic breathing movements driven by the brainstem rely on chemosensory inputs to homeostatically adjust motor output to the prevailing metabolic demand. The central CO

methodsIn our recent work, we demonstrated that chronic ETO treatment improved the CO

resultsOur results confirm dose-dependent impairment of the CO

conclusionIn contrast, male rats failed to show significant recovery with ETO treatment, suggesting a sex-specific mechanism through which ETO promotes CO

Indexed as

Chemoreceptor CellsDesogestrelHypoventilationReflexRespirationSleep Apnea, CentralAnimalsCarbon DioxideDisease Models, AnimalFemaleMaleProgestinsRatsRats, Sprague-DawleySex CharacteristicsCarbon DioxideDesogestreletonogestrelProgestinsCO2 chemoreflexetonogestrelprogesteronerespirationretrotrapezoid nucleussex differences

Identifiers

PMID41823358
PMCPMC12984012

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.