ArticleThe Journal of physiology2026
Acute cardio-centric haemodynamic management preserves chronic cardiovascular function in pigs with high-thoracic spinal cord injury.
Alexandra M Williams, Neda Manouchehri, Keerit Tauh, Megan Webster, Erin Erskine, Kitty So, Shera Fisk, Audrey Warner, Avril Billingsley, Alex Munro and 4 more
Abstract read
In one paragraphArticle in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Alexandra M WilliamsInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.ORCID 0000-0003-1571-9168 Neda ManouchehriInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.
Keerit TauhInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.
Megan WebsterInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.ORCID 0000-0001-8615-6118 Erin ErskineInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.
Kitty SoInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.
Shera FiskInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.ORCID 0000-0002-7560-7718 Audrey WarnerInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.ORCID 0000-0001-5017-5413 Avril BillingsleyInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.
Alex MunroInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.
Seth TigchelaarInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.
Femke StreijgerInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.
Christopher R WestInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.ORCID 0000-0002-0815-4122 Brian K KwonInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.
Funding
Craig Nielsen Foundation 459 120Michael Smith Health Research BC Trainee Award #17 197U.S. Department of Defense W81XWH017-1-0660
6 · The paper itselfAbstract
Chronic high-level spinal cord injury (SCI) leads to a complex phenotype of long-term cardio-autonomic dysregulation. In the initial hours post-injury, cardio-centric management with dobutamine (DOB) can optimize cardiovascular haemodynamics and mitigate secondary injury compared with standard vasopressor-based management (i.e. norepinephrine, NE) in a porcine model of T2 SCI; however, any potential long-term benefits remain to be determined. We therefore sought to assess whether acute DOB treatment could mitigate cardiovascular dysfunction in the chronic setting of high-level SCI. Seventeen Yucatan minipigs with T2 SCI received acute management with DOB (2.5 µg kg
Indexed as
Cardiotonic AgentsDobutamineHemodynamicsSpinal Cord InjuriesAnimalsBlood PressureFemaleNorepinephrineSwineSwine, MiniatureVascular ResistanceCardiotonic AgentsDobutamineNorepinephrinecardiovascular physiologyleft ventriclespinal cord injury
Identifiers
PMID41823338
PMCPMC13039245
What OpenQuestion holds
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LicenceCC BY-NC
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