ReviewScience progress
Mechanisms of the brain-gut-bone axis on bone metabolism: Mediated by serotonin (5-HT) and associated molecules.
Review in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Impact of microbiome alterations on fracture healing and nonunion: a narrative review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain-gut-bone axis refers to the interactions among the brain, gut, and bones, which were developed and refined by researchers across multiple fields. This axis was complex and dynamic, and influenced overall health through any possible intervention. This narrative review primarily focused on the regulation of bone metabolism through this axis mediated by serotonin (5-hydroxytryptamine (5-HT)) and mediators. Bone metabolism, influenced by various factors, was characterized by dynamic processes occurring within bone tissue, including bone formation and resorption. To enhance bone metabolism, it was essential to consider the brain-gut-bone axis, offering new insights in clinical research. This review examined the influence of the brain-gut-bone axis on bone metabolism and its underlying mechanisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.