Evidence map›Paper›PMID 41822972›Full record

ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026

Time from pre-labor rupture of membrane at term to delivery in grand multiparous women.

Shai Ram, Michael Lavie, Roy Bitan, David Nadav Sabag, Dotan Madar, Anat Lavie, Yariv Yogev, Roza Berkovitz Shperling

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Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Shai RamLis Hospital for Women's Health, Tel Aviv Sourasky Medical Center, Affiliated to the Gray Faculty of Medicine and Health Science, Tel Aviv University, Tel Aviv, Israel.
Michael LavieLis Hospital for Women's Health, Tel Aviv Sourasky Medical Center, Affiliated to the Gray Faculty of Medicine and Health Science, Tel Aviv University, Tel Aviv, Israel.ORCID https://orcid.org/0000-0002-8431-8563
Roy BitanLis Hospital for Women's Health, Tel Aviv Sourasky Medical Center, Affiliated to the Gray Faculty of Medicine and Health Science, Tel Aviv University, Tel Aviv, Israel.
David Nadav SabagLis Hospital for Women's Health, Tel Aviv Sourasky Medical Center, Affiliated to the Gray Faculty of Medicine and Health Science, Tel Aviv University, Tel Aviv, Israel.
Dotan MadarLis Hospital for Women's Health, Tel Aviv Sourasky Medical Center, Affiliated to the Gray Faculty of Medicine and Health Science, Tel Aviv University, Tel Aviv, Israel.
Anat LavieLis Hospital for Women's Health, Tel Aviv Sourasky Medical Center, Affiliated to the Gray Faculty of Medicine and Health Science, Tel Aviv University, Tel Aviv, Israel.
Yariv YogevLis Hospital for Women's Health, Tel Aviv Sourasky Medical Center, Affiliated to the Gray Faculty of Medicine and Health Science, Tel Aviv University, Tel Aviv, Israel.
Roza Berkovitz ShperlingLis Hospital for Women's Health, Tel Aviv Sourasky Medical Center, Affiliated to the Gray Faculty of Medicine and Health Science, Tel Aviv University, Tel Aviv, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe effect of parity on labor progression following term pre-labor rupture of membranes (PROM) has been described, but detailed patterns among grand multiparous women remain unclear. Traditional labor models show accelerated labor with increasing parity, yet few studies have specifically examined PROM latency distributions or heterogeneity within high-parity groups. The aim of the present study was to characterize labor progression after term PROM across parity groups, with specific focus on identifying heterogeneity and distinct distributional patterns among grand multiparous women.

methodsThis was a retrospective cohort study including 11 219 women with singleton, cephalic pregnancies at ≥37 weeks gestation who underwent expectant management following term PROM. Women were stratified into three groups: nulliparous (n = 4347), multiparous parity 1-4 (n = 6725), and grand multiparous parity ≥5 (n = 147). The primary outcome was PROM-to-delivery interval analyzed by mean, median, and percentile distribution. Secondary outcomes included mode of delivery and second-stage duration.

resultsMean PROM-to-delivery interval decreased with increasing parity (nulliparous 13.4 ± 7.1 h vs multiparous 10.4 ± 6.3 h vs grand multiparous 10.2 ± 6.5 h; P < 0.001). While grand multiparous women had labor kinetics comparable to multiparous women at lower percentiles, a biphasic pattern emerged: beyond the 70th percentile, latency in grand multiparous women plateaued and resembled nulliparous progression. Grand multiparous women had the shortest second stage (14.3 ± 9.8 min) and highest spontaneous vaginal delivery rate (96.6%).

conclusionBeyond confirming known parity-related differences in labor duration after term PROM, this study demonstrates clinically relevant heterogeneity within the grand multiparous population. A distinct subgroup shows delayed progression that is not captured by mean or median estimates. Distributional, percentile-based assessment may refine counseling and support more individualized timing of intervention following term PROM.

Indexed as

Delivery, ObstetricLabor, ObstetricParityPremature Rupture of Fetal MembranesAdultFemaleHumansPregnancyRetrospective StudiesTime Factorsgrand multiparitylabor progressionparitypre‐labor rupture of membranes (PROM)vaginal delivery

Identifiers

PMID41822972
PMCPMC13505241

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.