Evidence map›Paper›PMID 41822963›Full record

ArticleStroke2026

Temporal Trends of Emergency Department Acute Ischemic Stroke Care in a Community Without an Academic Medical Center.

Amanda Malingagio, Elizabeth Do, Alexander Cooper, Robert Miller, Regina Royan, Darin B Zahuranec, Brook Danboise, Alainya Tomanec, Brian Stamm, Lynda D Lisabeth and 4 more

Abstract read
In one paragraph

Article in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Amanda MalingagioStroke Program, Department of Neurology (A.M., A.C., R.M., R.R., D.B.Z., B.S., L.D.L., W.J.M., L.B.M.), University of Michigan Medical School, Ann Arbor.ORCID 0009-0009-4030-6649
Elizabeth DoStroke Program, Department of Neurology (A.M., A.C., R.M., R.R., D.B.Z., B.S., L.D.L., W.J.M., L.B.M.), University of Michigan Medical School, Ann Arbor.
Alexander CooperStroke Program, Department of Neurology (A.M., A.C., R.M., R.R., D.B.Z., B.S., L.D.L., W.J.M., L.B.M.), University of Michigan Medical School, Ann Arbor.
Robert MillerStroke Program, Department of Neurology (A.M., A.C., R.M., R.R., D.B.Z., B.S., L.D.L., W.J.M., L.B.M.), University of Michigan Medical School, Ann Arbor.ORCID 0000-0003-4538-5779
Regina RoyanStroke Program, Department of Neurology (A.M., A.C., R.M., R.R., D.B.Z., B.S., L.D.L., W.J.M., L.B.M.), University of Michigan Medical School, Ann Arbor.ORCID 0000-0002-2645-5412
Darin B ZahuranecStroke Program, Department of Neurology (A.M., A.C., R.M., R.R., D.B.Z., B.S., L.D.L., W.J.M., L.B.M.), University of Michigan Medical School, Ann Arbor.ORCID 0000-0002-9772-2469
Brook DanboiseDepartment of Emergency Medicine (E.D., B.D., A.T.), CHRISTUS Spohn, Corpus Christi, TX.ORCID 0000-0002-5455-4426
Alainya TomanecDepartment of Emergency Medicine (E.D., B.D., A.T.), CHRISTUS Spohn, Corpus Christi, TX.ORCID 0000-0002-4165-8680
Brian StammStroke Program, Department of Neurology (A.M., A.C., R.M., R.R., D.B.Z., B.S., L.D.L., W.J.M., L.B.M.), University of Michigan Medical School, Ann Arbor.ORCID 0000-0002-0862-9650
Lynda D LisabethStroke Program, Department of Neurology (A.M., A.C., R.M., R.R., D.B.Z., B.S., L.D.L., W.J.M., L.B.M.), University of Michigan Medical School, Ann Arbor.ORCID 0000-0001-5539-5933
William J MeurerStroke Program, Department of Neurology (A.M., A.C., R.M., R.R., D.B.Z., B.S., L.D.L., W.J.M., L.B.M.), University of Michigan Medical School, Ann Arbor.ORCID 0000-0002-1158-5302
Morgan S CampbellDepartment of Neurology (M.S.C.), CHRISTUS Spohn, Corpus Christi, TX.ORCID 0009-0000-4659-4818
Faheem SheriffDepartment of Neurology, Texas Tech University Health Sciences Center, El Paso (F.S.).ORCID 0000-0002-3875-6175
Lewis B MorgensternStroke Program, Department of Neurology (A.M., A.C., R.M., R.R., D.B.Z., B.S., L.D.L., W.J.M., L.B.M.), University of Michigan Medical School, Ann Arbor.ORCID 0000-0002-5787-592X

Funding

Emergency Medicine Research Career Development Program in the Neurological Sciences (EMRCDP-NS)K12NS137516 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Opeolu M Adeoye, Clifton W. Callaway · 2024 to 2026
$7.9M
Brain Attack Surveillance in Corpus Christi (BASIC) ProjectR37NS038916 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYNDA D LISABETH, LEWIS B MORGENSTERN · 2024 to 2026
$3.7M
NINDS NIH HHS K12 NS137516NINDS NIH HHS R37 NS038916
6 · The paper itself

Abstract

backgroundTimely identification and treatment of acute ischemic stroke (AIS) in the emergency department is imperative. We sought to report the change over time in emergency department-based AIS treatment in a community without an academic medical center through a mixed-methods approach.

methodsAs part of the longitudinal population-based BASIC (Brain Attack Surveillance in Corpus Christi) project, Nueces County residents 45+ years old with AIS treated in an emergency department were identified, excluding patients with in-hospital events. Logistic regression was used to model changes over time from 2012 to 2022, treating time continuously, for the binary outcomes National Institutes of Health Stroke Scale score documentation, transfer to an out-of-area facility, thrombolytic (tPA/TNK [tissue-type plasminogen activator/tenecteplase]) utilization, and arrival method. Trends for neurology consults and telestroke consults were evaluated from 2015 to 2022 based on data availability. Logistic regression models accounted for subject repeated measures and within-hospital clustering. Rapid qualitative analysis procedures were used to analyze semistructured interviews of emergency medicine (EM) physicians.

resultsA total of 5388 strokes were included. National Institutes of Health Stroke Scale documentation by provider increased by 12.9% (95% CI, 0.057-0.202). The overall proportion of neurology consultation increased by 26% (95% CI, 0.159-0.360). Among these, the proportion of telestroke consults increased by 34.2% (95% CI, 0.218-0.465). Patient transfer to an out-of-area facility saw a peak around 2020 (3.2%) that declined by 2022 (0.0%). tPA/TNK treatment increased by 5.5%, but was not statistically significant (95% CI, -0.006 to 0.116). Arrival to the emergency department by emergency medical services decreased by 9.4% (95% CI, -0.181 to -0.007). Fifty-two practicing emergency medicine physicians in Nueces County were recruited via email between April and October 2024, yielding 18 interviews. Participants described improved organization of stroke care and confidence in treating AIS.

conclusionsThere have been positive changes in AIS treatment from the emergency medicine perspective, suggesting the success of assertive treatment protocols in this real-world community.

Indexed as

Emergency Service, HospitalIschemic StrokeAcademic Medical CentersAgedAged, 80 and overBrain IschemiaFemaleFibrinolytic AgentsHumansLongitudinal StudiesMaleMiddle AgedThrombolytic TherapyTissue Plasminogen ActivatorFibrinolytic AgentsTissue Plasminogen Activatoracademic medical centersemergency medicineischemic stroketenecteplasethrombectomy

Identifiers

PMID41822963
PMCPMC12991427

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.