ArticleFrontiers in medicine2026
Influence of antiviral treatment in hepatitis C patients on metabolism and fibrosis process.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Chronic Hepatitis C Virus (HCV) infection is associated with systemic metabolic disturbances, including glucose intolerance, lipid dysregulation, and inflammation, accelerating liver fibrosis and increasing hepatocellular carcinoma risk. Biomarkers such as Glucagon-Like Peptide-1 (GLP-1), Fatty Acid-Binding Protein 1 (FABP-1), Monocyte Chemoattractant Protein-1 (MCP-1), Angiopoietin-Like Protein 6 (ANGPTL6), ibroblast Growth Factor 19 (FGF-19), and ghrelin offer insights into these mechanisms and may reflect the impact of antiviral treatments. Objectives: This study evaluated the effects of two direct-acting antiviral (DAA) regimens-Glecaprevir/Pibrentasvir (G/P) and Sofosbuvir/Velpatasvir (S/V)-on metabolic and inflammatory biomarkers in 70 HCV-infected patients with comorbidities including obesity, type 2 diabetes, and hypertension. Methods: Serum biomarker levels were assessed pre- and post-treatment using the Luminex FlexMAP 3D system. Patients were stratified by treatment type, fibrosis stage (F0-F4), and baseline cholesterol. Liver stiffness was evaluated via FibroScan. Results: Both regimens induced significant biomarker changes. ANGPTL6, FGF-19, ghrelin, total cholesterol, HDL, and non-HDL increased, while FABP-1 and MCP-1 decreased, indicating reduced inflammation and lipid stress. Stronger effects were seen in patients with lower baseline cholesterol and with S/V in advanced fibrosis. G/P showed marked anti-inflammatory effects in early fibrosis. Conclusion: DAA therapy significantly alters metabolic and inflammatory biomarkers in HCV patients, with regimen- and fibrosis stage-specific effects. S/V may provide broader metabolic benefits in advanced disease, while G/P offers stronger anti-inflammatory responses earlier, supporting personalized treatment approaches.
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