ArticleHealth science reports2026
Establishment of Age-Specific Reference Intervals for 16 Coagulation Parameters in Chinese Children Using Sysmex CN-6000 Analyzer: A Cross-Sectional Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Children's coagulation system undergoes dynamic changes during development, necessitating age-specific reference intervals (RIs). This study aimed to establish RIs for 16 coagulation parameters in Chinese children aged 0-18 years using the Sysmex CN-6000 analyzer. Methods: We conducted a cross-sectional study in children aged 0 day to 18 years who met the inclusion and exclusion criteria. Participants were stratified into six age groups (0-30 days, 1-6 months, 6-12 months, 1-3 years, 3-12 years, and 12-18 years) and blood samples were collected. Routine parameters (APTT, PT, PT-INR, TT, Fibrinogen [Fib]), thrombotic markers (AT-III, D-Dimer [D-Di], Fibrin Degradation Products [FDP]), and coagulation factors (II, V, VII, VIII, IX, X, XI, XII) were analyzed using the Sysmex CN-6000 analyzer. RIs and their 90% confidence intervals (CIs) were calculated using the non-parametric method (for Results: Neonates exhibited distinct coagulation profiles, including prolonged APTT (22.7 s-46.5 s) and TT (16.2 s-20.8 s), reduced levels of anticoagulant and coagulation factors (e.g., AT-III: 23.1%-91.3%, factor II: 26.5%-77.5%), and elevated fibrinolytic markers (D-Di ≤ 1.41 μg/mL; FDP ≤ 4.44 μg/mL). Age-dependent trends were evident: APTT shortened until adolescence (24.7 s-32.9 s), while factor IX increased progressively (16.3% - 43.2% in neonates vs. 43.6%-108.6% in adolescents). Novel RIs for neonatal D-Di and FDP were established, addressing a critical gap in developmental hemostasis. Sex-specific differences in TT were observed but deemed clinically insignificant. Conclusion: Age-specific RIs are essential for children. This study provides the first comprehensive RIs for Sysmex CN-6000 in Chinese children, aiding in the diagnosis and management of coagulation disorders in pediatrics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.