Evidence map›Paper›PMID 41822759›Full record

ArticleFrontiers in genetics2026

Lung scRNA-seq reveals chronic inflammation and emphysemous phenotype in mice with osteogenesis imperfecta.

Jennifer Zieba, Roya Bagheri, Alex Kot, Jorge H Martin, Davis Wachtell, Sereen Wong, Maeve Mungovan, Caroline Wight, Deborah Krakow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jennifer ZiebaDepartment of Orthopaedic Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States.
Roya BagheriDepartment of Orthopaedic Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States.
Alex KotDepartment of Human Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States.
Jorge H MartinDepartment of Orthopaedic Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States.
Davis WachtellDepartment of Orthopaedic Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States.
Sereen WongDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, United States.
Maeve MungovanDepartment of Orthopaedic Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States.
Caroline WightDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, United States.
Deborah KrakowDepartment of Orthopaedic Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States.

Funding

Investigating pulmonary complications due to abnormal collagen/ER stress in Osteogenesis ImperfectaR01HL160554 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jennifer Zieba · 2023 to 2026
$1.6M
NHLBI NIH HHS R01 HL160554
6 · The paper itself

Abstract

Osteogenesis imperfecta (OI), or brittle bone disease, is a rare congenital disorder characterized by bone fragility and increased fracture incidence mainly due to mutations in type I collagen or genes associated with collagen synthesis. Genetic and allelic heterogeneity underlie the phenotypic spectrum of OI yet all forms commonly feature early mortality stemming from pulmonary complications, the molecular cause for which has not been resolved. Using single-cell RNA sequencing (scRNAseq), we identified novel molecular and cellular mechanisms underlying the lung abnormalities observed in our

Indexed as

airway inflammationcell-cell communicationemphysemaextracellular matrixinterstitial lung diseaseosteogenesis imperfectasingle-cell RNA-sequencing

Identifiers

PMID41822759
PMCPMC12978693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.