ArticleTurkish journal of biology = Turk biyoloji dergisi2026
Human bone marrow-mesenchymal stem cells differentiation into brain-like endothelial cells.
Article in Turkish journal of biology = Turk biyoloji dergisi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Background/Aim: Brain microvascular endothelial cells (BMECs), which constitute the blood-brain barrier (BBB), are essential for maintaining central nervous system homeostasis. Like BMECs, multipotent mesenchymal stem cells (MSCs) originate from the mesodermal lineage. Thus, MSCs may serve as a direct and efficient cellular source for BMEC-like differentiation. Notably, differentiation of human induced pluripotent stem cells (hiPSCs) into BMECs typically involves a 2-step protocol: inducing mesodermal commitment followed by endothelial specification. In contrast, direct differentiation from MSCs could bypass the initial mesodermal induction step, offering a streamlined alternative. This study tested a novel strategy for differentiating MSCs into brain-like endothelial cells (BLECs), circumventing the conventional mesodermal induction step. Materials and methods: Our differentiation protocol integrates developmental cues through the application of hypoxia, retinoic acid (RA), cobalt chloride (CoCl Results: Immunocytochemical analysis confirmed the expression of key BMEC markers, including ZO-1, CD31, and occludin, showing both phenotypic and functional characteristics of brain microvascular endothelium. Conclusion: This MSC-based differentiation approach provides a robust and physiologically relevant in vitro BBB model with potential applications in studying neurological disease mechanisms and screening therapeutic agents.
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