Evidence map›Paper›PMID 41822693›Full record

ArticlemedRxiv : the preprint server for health sciences2026

An Exploratory Study of Host Plasma Proteomic Signatures that Distinguish Active Syphilis in Adults.

Cody Chou, Shad R Morton, Kelika A Konda, Silver Vargas, Michael Reyes-Diaz, Francesca Vasquez, Carlos F Caceres, Jeffrey D Klausner, Trey Toombs, Rushdy Ahmad and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Cody ChouHarvard University, Boston, MA, USA.ORCID 0000-0002-5431-7842
Shad R MortonWyss Institute, Boston, MA, USA.
Kelika A KondaDepartment of Medicine and Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Silver VargasUnit of Health, Sexuality and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru.
Michael Reyes-DiazUnit of Health, Sexuality and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru.
Francesca VasquezUnit of Health, Sexuality and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru.
Carlos F CaceresUnit of Health, Sexuality and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru.
Jeffrey D KlausnerDepartment of Medicine and Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Trey ToombsWyss Institute, Boston, MA, USA.
Rushdy AhmadWyss Institute, Boston, MA, USA.
Lao-Tzu Allan-BlitzDivision of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Funding

Syphilis Immunology and Biology to Improve Clinical Management and Vaccine DesignR01AI139265 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jeffrey David Klausner · 2018 to 2026
$4.8M
The development & pilot implementation of a CRISPR-based low-cost point-of-care assay for detecting Neisseria gonorrhoeae and molecular markers of antimicrobial resistance in resource-limited settingsK23AI182453 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Lao-Tzu Allan-Blitz · 2024 to 2026
$585k
NIAID NIH HHS K23 AI182453NIAID NIH HHS R01 AI139265
6 · The paper itself

Abstract

Syphilis remains a major public health concern. However, current serologic assays are limited in their ability to distinguish active from previously treated disease. We applied tandem mass tag-based quantitative proteomics to plasma from 10 adults with active syphilis and 10 age- and gender-matched non-diseased controls. We identified 54 differentially regulated proteins (36 upregulated, 18 downregulated). Those proteins map to immune and inflammatory responses, acute-phase signaling, coagulation and vascular pathways, and cellular stress processes. Three sets of between 2-5 proteins achieved ≥99% discrimination between cases and controls. Our exploratory findings support proteomics as a potential tool to develop novel syphilis diagnostics.

Indexed as

BiomarkersDiagnostic developmentHost immune responseInflammatory pathwaysMass spectrometryProteomicsSyphilisTreponema pallidum

Identifiers

PMID41822693
PMCPMC12976908

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.