ArticlemedRxiv : the preprint server for health sciences2026
Airborne particulate matter enhances with monosodium urate crystals the secretion of IL-1β by human immune cells.
Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gout is driven by an interleukin-1β-mediated intense innate immune reaction to monosodium urate (MSU) crystals (MSUc). In cell culture models of inflammatory gout there is a synergistic effect of phagocytosis of MSUc and TLR2 and TLR4 activation by agonists such as free fatty acid and lipopolysaccharide (LPS) in NLRP3-inflammasome activation and IL-1β secretion. A substantial number of gout patients do not report a dietary trigger, and observational studies associate airborne particulate matter with incident gout and flares. Airborne particulate matter contains LPS and airborne-derived particulate matter stimulates IL-1β secretion in cell culture. We hypothesized that air-borne particulate matter could co-stimulate, with MSUc, IL-1β secretion and inflammation. We tested the hypothesis using MSUc with extracted airborne PM
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