Evidence map›Paper›PMID 41822676›Full record

ArticleCureus2026

Leber Hereditary Optic Neuropathy Caused by the Rare MT-ND1 m.3394T>C Mutation: A Case With Favorable Visual Prognosis and a Literature Review.

Paulina Mikulenaite, Alvita Vilkeviciute, Almina Stramkauskaite, Ieva Povilaityte, Neringa Jurkute, Rasa Liutkeviciene

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In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paulina MikulenaiteDepartment of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LTU.
Alvita VilkeviciuteLaboratory of Ophthalmology, Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LTU.
Almina StramkauskaiteDepartment of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LTU.
Ieva PovilaityteDepartment of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LTU.
Neringa JurkuteBiomedical Research Centre, National Institute for Health and Care Research (NIHR), London, GBR.
Rasa LiutkevicieneLaboratory of Ophthalmology, Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LTU.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leber hereditary optic neuropathy (LHON) is an inherited mitochondrial optic neuropathy characterized by acute or subacute painless central visual loss. Most cases are associated with three primary mitochondrial DNA mutations; however, rare variants remain incompletely characterized. Early diagnosis is essential for appropriate management and genetic counseling. We report the case of a 51-year-old Lithuanian woman who presented with painless, progressive central visual loss. Initial neurological and ophthalmological investigations were unremarkable, and corticosteroid therapy was ineffective. Genetic testing revealed a rare homoplasmic m.3394T>C mutation in the

Indexed as

aetiologydiagnosisleber hereditary optic neuropathymt-nd1 gene (m.3394t>c)treatment

Identifiers

PMID41822676
PMCPMC12977287

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.