ArticleCureus2026
An Unusual First Presentation of Colon Cancer: Pulmonary Lymphangitic Carcinomatosis.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
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Abstract
Pulmonary lymphangitic carcinomatosis (PLC) is a rare manifestation of metastatic disease that presents with nonspecific respiratory symptoms. We describe a young male who presented with progressive dyspnea and cough and was initially managed for pneumonia. Chest imaging demonstrated diffuse interstitial abnormalities with mediastinal lymphadenopathy and pleural effusions, prompting evaluation for interstitial lung disease (ILD). Extensive infectious and rheumatologic testing was unrevealing. Cytologic analysis of pleural fluid revealed adenocarcinoma, and subsequent imaging identified a primary sigmoid colon malignancy. Despite the initiation of chemotherapy, the patient rapidly deteriorated. This case underscores the diagnostic challenges of PLC and emphasizes the importance of maintaining a broad differential diagnosis in patients with persistent respiratory symptoms and imaging findings similar to ILD. It also highlights the importance of considering occult colorectal malignancy in cases of PLC.
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