Evidence map›Paper›PMID 41822600›Full record

ArticleCureus2026

Treating Acute Toxo-Metabolic Encephalopathy With Continuous Renal Replacement Therapy: A Case Report of Ifosfamide Neurotoxicity.

Bilal Shahzad Azam Khan, Sumayya Din Bashir

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bilal Shahzad Azam KhanDepartment of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.
Sumayya Din BashirDepartment of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute toxometabolic encephalopathy, which encompasses delirium and the acute confusional state, is a condition of global cerebral dysfunction in the absence of primary structural brain disease. Ifosfamide is an alkylating agent used in chemotherapy for the treatment of hematological and various solid tumors and is associated with dose-dependent central nervous system toxicity. We report a case of a patient who developed severe neurological symptoms and encephalopathy after receiving Ifosfamide, a chemotherapy agent. Despite initial management with intravenous methylene blue, the patient continued to deteriorate. Initiation of continuous venovenous hemodialysis 14 hours after symptom onset resulted in rapid and complete recovery.

Indexed as

acute kidney injuryacute toxometabolic encephalopathycontinuous renal replacement therapyifosfamidevolume of distribution

Identifiers

PMID41822600
PMCPMC12976646

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.