Evidence map›Paper›PMID 41822521›Full record

ArticleFrontiers in immunology2026

Alleviation of experimental arthritis in SKG mice through

Yoichi Nakayama, Ryosuke Hiwa, Ayaka Okubo, Mikihito Shoji, Mirei Shirakashi, Hideaki Tsuji, Koji Kitagori, Ran Nakashima, Shuji Akizuki, Hajime Yoshifuji and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yoichi NakayamaDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ryosuke HiwaDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ayaka OkuboDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Mikihito ShojiDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Mirei ShirakashiDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hideaki TsujiDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Koji KitagoriOccupational Welfare Division, Agency for Health, Safety and Environment, Kyoto University, Kyoto, Japan.
Ran NakashimaDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Shuji AkizukiDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hajime YoshifujiDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Akio MorinobuDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Rheumatoid arthritis (RA), a chronic autoimmune disease, is characterized by CD4 Methods: The SKG mouse model of T cell-dependent chronic arthritis was constructed via zymosan A induction. The mice were intraperitoneally treated with CsnB, and disease severity and immune cell populations were evaluated by clinical scoring and flow cytometry. Results: CsnB markedly attenuated arthritis development and reduced the population of effector memory and Th17 cells in the spleen and synovium. Furthermore, Discussion: Altogether, the findings of this study showed that CsnB, one of the agonists of

Indexed as

Arthritis, ExperimentalArthritis, RheumatoidNuclear Receptor Subfamily 4, Group A, Member 1AnimalsCell DifferentiationCytokinesDisease Models, AnimalLymphocyte ActivationMaleMicePhenylacetatesTh17 CellsCytokinescytosporone BNr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1PhenylacetatesCytosporone Bexperimental arthritisNR4Arheumatoid arthritisSKG miceT cell antigen receptor signalingT cells

Identifiers

PMID41822521
PMCPMC12976022

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.