Evidence map›Paper›PMID 41822520›Full record

ReviewFrontiers in immunology2026

The SIRP family: from structural diversity and signaling mechanisms to implications in immune-related disease targeted therapeutics.

Yanmei Jin, Quiyang Huang, Jiaqi Song, Zain Ul Abideen, Ruijiong Tan, Shaohua Xu, Ming Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanmei JinState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China.
Quiyang HuangState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China.
Jiaqi SongState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China.
Zain Ul AbideenState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China.
Ruijiong TanState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China.
Shaohua XuState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China.
Ming ChenState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Signal regulatory proteins (SIRPs) are membrane receptors on immune cells that control immune homeostasis and inflammation. Although SIRP family members share homologous extracellular domains, they differ in intracellular motifs and function: SIRPα transduces inhibitory signals, SIRPβ associates with DAP12 to trigger activation, and SIRPγ primarily modulates adhesion and T cell responses. This review compares the structure, ligand interactions, and signaling mechanisms of SIRPα, SIRPβ, and SIRPγ, summarizes their roles in cancer, autoimmunity and neurodegeneration, and surveys therapeutic strategies that target the CD47-SIRPα axis. We highlight current clinical progress, common toxicities, and open questions that must be addressed to advance SIRP-targeted therapies.

Indexed as

Antigens, DifferentiationReceptors, ImmunologicSignal TransductionAnimalsAutoimmune DiseasesCD47 AntigenHumansMolecular Targeted TherapyNeoplasmsAntigens, DifferentiationCD47 AntigenReceptors, ImmunologicSIRPA protein, humanautoimmune diseaseCD47immune regulationphagocytosisSIRP familytumor immune escape

Identifiers

PMID41822520
PMCPMC12975943

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.