Evidence map›Paper›PMID 41822512›Full record

ArticleFrontiers in immunology2026

The Nrf2-SLPI axis in aging and its role in the pathophysiology of pulmonary

Sosuke Matsumura, Masashi Matsuyama, Masayuki Nakajima, Chio Sakai, Kodai Ueda, Mizu Nonaka, Kengo Nishino, Zhenting Wei, Yuki Yabuuchi, Kenya Kuramoto and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sosuke MatsumuraDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Masashi MatsuyamaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Masayuki NakajimaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Chio SakaiDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Kodai UedaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Mizu NonakaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Kengo NishinoDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Zhenting WeiDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Yuki YabuuchiDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Kenya KuramotoDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Kai YazakiDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Kazufumi YoshidaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Takumi KiwamotoDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Yuko MorishimaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Yukio IshiiDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Masafumi MurataniDepartment of Genome Biology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Nobuyuki HizawaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is associated with a poor prognosis in pulmonary

Indexed as

AgingMycobacterium avium ComplexMycobacterium avium-intracellulare InfectionNF-E2-Related Factor 2Secretory Leukocyte Peptidase InhibitorAgedAge FactorsAnimalsDisease Models, AnimalFemaleHumansIsothiocyanatesLungMaleMiceMice, Inbred C57BLIsothiocyanatesNFE2L2 protein, humanNfe2l2 protein, mouseNF-E2-Related Factor 2Secretory Leukocyte Peptidase InhibitorSLPI protein, humanSlpi protein, mousesulforaphaneSulfoxidesagingNrf2pulmonary Mycobacterium avium complex (MAC) diseaseRNA-seqsecretory leukocyte protease inhibitor (SLPI)

Identifiers

PMID41822512
PMCPMC12975742

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.