Evidence map›Paper›PMID 41822498›Full record

ArticleFrontiers in immunology2026

EEG biomarkers of microstructural damage in normal-appearing white matter among patients with neuromyelitis optica spectrum disorder: A DTI-EEG combined study.

Lili Yang, Hui Qiu, Yun Qin, Zijun Li, Congyu Xu, Yan Xie, Kai Chen, Shuai Ma, Lingling Dong, Dezhong Yao and 2 more

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Lili Yang *Department of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Hui Qiu *Department of Radiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Yun QinKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Zijun LiKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Congyu XuChengdu Techman Software Co., Ltd, Chengdu, China.
Yan XieDepartment of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Kai ChenDepartment of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Shuai MaDepartment of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Lingling DongDepartment of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Dezhong YaoKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Rui HuangDepartment of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Song TanDepartment of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to explore the potential of EEG in monitoring the extent of white matter microstructural damage in patients with neuromyelitis optica spectrum disorder (pwNMOSD) for the first time. Methods: Thirty-two pwNMOSD and 20 healthy controls were recruited and all received DTI scan, while the pwNMOSD underwent also resting state EEG (rs-EEG). DTI indices were compared between two groups to identify impaired WM tracts in pwNMOSD. Correlations between the 240 rs-EEG indices (including spectral and functional connectivity indices in five frequency bands of six brain regions) and the fractional anisotropy (FA) of the impaired WM fiber tract were calculated to identify the rs-EEG biomarkers of WM microstructural damage. The relationships of the identified rs-EEG biomarkers with disease characteristics and cognitive function were further analyzed. Results: Seventeen of the 20 main WM tracts were found to have microstructural damage in pwNMOSD. The functional connectivity indices were significantly and positively correlated with the FA of WM tracts in pwNMOSD, especially the coherence and phase locking value strengths in the theta and gamma frequency bands (r=0.40-0.61). Different patterns between the rs-EEG indices in different frequency bands and the integrity of WM tracts were revealed. These identified rs-EEG indices were significantly related to patients' disease characteristics (number of attacks (r=-0.44), expanded disability status scale score (r=-0.41--0.47), serum anti-glial fibrillary acidic protein level (r=-0.43)) and cognitive functions (symbol digit modality test score, r=0.46).

Indexed as

Diffusion Tensor ImagingElectroencephalographyNeuromyelitis OpticaWhite MatterAdultBiomarkersFemaleHumansMaleMiddle AgedBiomarkersdiffusion tensor imagingfunctional connectivityneuromyelitis opticaresting-state EEGwhite matter microstructural damage

Identifiers

PMID41822498
PMCPMC12975549

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