Evidence map›Paper›PMID 41822373›Full record

ArticleOpen forum infectious diseases2026

Characteristics of Young Children Hospitalized With Acute Respiratory Failure From Infection With Respiratory Syncytial Virus, SARS-CoV-2, or Both, November 2023-March 2024.

Regina M Simeone, Margaret M Newhams, Laura D Zambrano, Jemima M Calixte, Katherine Lindsey, Amber Orzel-Lockwood, Amanda B Payne, Natasha B Halasa, Satoshi Kamidani, Aline B Maddux and 25 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Regina M SimeoneCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-2779-3747
Margaret M NewhamsDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-3738-1172
Laura D ZambranoCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-0145-9142
Jemima M CalixteDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Katherine LindseyCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-5891-4233
Amber Orzel-LockwoodDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Amanda B PayneCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-1027-7639
Natasha B HalasaDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee,USA.ORCID https://orcid.org/0000-0002-6381-1826
Satoshi KamidaniThe Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and the Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-6829-0700
Aline B MadduxDepartment of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0002-0949-4284
Kathleen ChiotosDivision of Critical Care Medicine, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-0204-8708
Hillary CrandallDivision of Pediatric Critical Care, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0002-5392-8457
Jennifer E SchusterDivision of Pediatric Infectious Diseases, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.ORCID https://orcid.org/0000-0001-6365-566X
Danielle M ZerrDivision of Infectious Diseases, Department of Pediatrics, University of Washingtonand Seattle Children's Research Institute, Seattle, Washington, USA.ORCID https://orcid.org/0000-0003-2944-7554
Lora M MartinDepartment of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA.ORCID https://orcid.org/0009-0000-7750-8468
Melissa A CameronDivision of Pediatric Hospital Medicine, UC San Diego-Rady Children's Hospital, San Diego, California, USA.ORCID https://orcid.org/0000-0003-3710-0809
Katherine IrbySection of Pediatric Critical Care, Department of Pediatrics, Arkansas Children's Hospital, Little Rock, Arkansas, USA.ORCID https://orcid.org/0000-0001-8111-3215
Shira J GertzDivision of Pediatric Critical Care, Department of Pediatrics, Cooperman Barnabas Medical Center, Livingston, New Jersey, USA.ORCID https://orcid.org/0000-0001-8119-6006
Steven L SheinDepartment of Pediatrics, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0003-3382-5159
Ryan A NofzigerDivision of Critical Care Medicine, Department of Pediatrics, Akron Children's Hospital, Akron, Ohio, USA.ORCID https://orcid.org/0000-0001-7057-2686
Samina S BhumbraRyan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0002-4036-0479
Janet R HumeDivision of Pediatric Critical Care, University of Minnesota Masonic Children's Hospital, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-8891-6800
Michele KongDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0001-6596-3965
Mia MaamariDepartment of Pediatrics, Division of Critical Care Medicine, Children's Medical Center Dallas, University of Texas Southwestern, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-0118-1638
Bria M CoatesDivision of Pediatric Critical Care Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-4264-5440
Judith A Guzman-CottrillDepartment of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-3792-4405
Mary Allen StaatDepartment of Pediatrics, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0003-1788-8037
Thomas J ConnorsDivision of Child and Adolescent Health, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, NewYork, New York, USA.ORCID https://orcid.org/0000-0002-0199-7733
Matt S ZinterDepartment of Pediatrics, Divisions of Critical Care Medicine and Allergy, Immunology, and Bone Marrow Transplant, University of California SanFrancisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0003-3351-3278
Jigar C ChauhanDivision of Pediatric Critical Care, Nemours Children's Hospital, Wilmington, Delaware, USA.ORCID https://orcid.org/0000-0003-2340-828X
Tamara T BradfordDivision of Cardiology, Department of Pediatrics, Louisiana State University Health Sciences Center and Children's Hospital of New Orleans, New Orleans, Louisiana, USA.ORCID https://orcid.org/0000-0001-5220-7423
Kari WellnitzDivision of Pediatric Critical Care, Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.ORCID https://orcid.org/0000-0001-9451-8879
Angela P CampbellCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-2576-482X
Adrienne G RandolphDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-3084-3071
Overcoming COVID-19 Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Respiratory syncytial virus (RSV) and SARS-CoV-2 can cause acute respiratory failure in children. We compared characteristics and outcomes of children aged <2 years with respiratory failure from infection with RSV, SARS-CoV-2, or both viruses. Methods: We used data from a US pediatric respiratory virus hospitalization surveillance network including children with ICU admission for acute respiratory failure (receiving high-flow oxygen or mechanical ventilation) with RSV and/or SARS-CoV-2 during November 2023-March 2024. Demographic, clinical characteristics, and hospitalization outcomes were stratified by a positive test for RSV, SARS-CoV-2, or both viruses, and compared using chi-squared or Kruskal-Wallis tests. Multivariable analyses assessed independent associations between outcomes and infection. Results: Overall, 1406 children were included: 1253 (89.1%) for RSV, 105 (7.5%) for COVID-19, and 48 (3.4%) with RSV + SARS-CoV-2 detected. Children with RSV or RSV + SARS-CoV-2 had lower median ages (3.9 and 5.4 months, respectively) compared with those with SARS-CoV-2 (8.8 months; Conclusions: Critically ill children <2 years of age infected with SARS-CoV-2 had more severe illness presentation and outcomes and were older compared with those with RSV and RSV + SARS-CoV-2 codetection. Most children were previously healthy, highlighting the need for prevention measures.

Indexed as

COVID-19pediatricrespiratory failurerespiratory syncytial virus

Identifiers

PMID41822373
PMCPMC12978529

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