ArticleFrontiers in cellular and infection microbiology2026
Biomarker-based diagnosis of ventilator-associated pneumonia using serum and bronchoalveolar lavage fluid levels of presepsin, procalcitonin, and lipopolysaccharide-binding protein.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Peripheral Blood Mononuclear Cells in Sepsis: Immune Trajectories, Monocyte Dysfunction, and Translational Biomarkers.Journal of inflammation research · 2026Review
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Abstract
Objective: Mechanically ventilated patients are often confronted with ventilator-associated pneumonia (VAP), showing an increased risk of mortality. Early identification of biomarkers associated with VAP may ease the diagnosis and guide preventive interventions. In this study, we investigated the diagnostic value of VAP using serum and bronchoalveolar lavage fluid (BALF) levels of presepsin, procalcitonin (PCT), and lipopolysaccharide-binding protein (LBP). Methods: The serum and BALF samples were collected from 300 consecutive mechanically ventilated patients with a clinical suspicion of VAP by bronchoscopy. Among these 300 patients, 126 patients had confirmed VAP, while 174 did not meet the criteria for VAP. Results: The reference ranges of serum presepsin, PCT, and LBP in patients with confirmed VAP were all higher than those in patients with VAP criteria not fulfilled ( Conclusion: Our findings point to the importance of selecting the correct biological fluid when analyzing molecular diagnostics for definitive VAP among mechanically ventilated patients with suspicion of VAP.
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