ArticleFrontiers in cellular and infection microbiology2026
The value of metagenomic next-generation sequencing in lower respiratory tract infections among critically ill patients in the ICU.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Metagenomic next-generation sequencing reveals microbial community characteristics during acute exacerbations of interstitial pneumonia and their associations with clinical phenotypes.Frontiers in cellular and infection microbiology · 2026Article
- Development and evaluation of a multiplex PCR-based dual-platform targeted sequencing framework for precise differentiation of lumpy skin disease virus.Frontiers in microbiology · 2026Article
- Next-generation sequencing in the etiological diagnosis of severe childhood pneumonia.Frontiers in pediatrics · 2026Review
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Authors and funding
7 authors.
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Abstract
Lower respiratory tract infections (LRTIs) frequently occur as a severe complication in intensive care unit (ICU) patients, substantially raising patient mortality rates and extending hospitalization periods. In this study, a retrospective cohort study of 261 suspected LRTI patients in the ICU of Nanjing Drum Tower Hospital between April 2021 and February 2024 was conducted. The results showed that metagenomic next-generation sequencing (mNGS) had a sensitivity of 80.1%, a specificity of 35%, and an accuracy of 66.3% across all samples. For pathogen detection, mNGS outperformed conventional microbiological testing (CMT) in detecting bacteria and DNA viruses, while CMT had a slight advantage in RNA virus detection, though the difference was not statistically significant (
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