Trial reportFrontiers in cellular and infection microbiology2026
Effects of Xipayi Gingival Solution combined with minocycline hydrochloride on inflammatory cytokines and masticatory function in patients with chronic periodontitis.
Trial report in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Objective: This study aimed to elucidate the therapeutic effects of Xipayi Gingival Solution (Xipayi Guyin Ye) combined with minocycline hydrochloride on inflammatory factors and masticatory function in patients with chronic periodontitis. Methods: Ninety-eight patients with chronic periodontitis were randomly allocated into two groups. Both groups underwent conventional periodontal therapy. The control group received minocycline hydrochloride once weekly for four weeks, while the combination group additionally used Xipayi Gingival Solution three times daily for four consecutive weeks. Periodontal health indicators (PD, AL, PLI, SBI, GI, GCFV), gingival crevicular fluid cytokines (hs-CRP, TNF-α, IL-1β, IL-6), serum oxidative stress markers (MDA, SOD, GSH-Px), masticatory function (CFQ), pain (VAS), clinical efficacy, and adverse reactions were compared. Results: Four control and two combination group patients withdrew. Finally, 45 and 47 patients completed treatment. Post-treatment, PD, AL, PLI, SBI, GI, and GCFV decreased in both groups, with lower values in the combination group ( Conclusion: Xipayi Gingival Solution combined with minocycline hydrochloride enhances periodontal status, mitigates inflammatory and oxidative stress responses, improves masticatory function, and relieves pain without increasing adverse events. The combined therapy demonstrates better clinical efficacy than minocycline alone, indicating a safe and effective therapeutic approach for chronic periodontitis.
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