ArticleFrontiers in gastroenterology (Lausanne, Switzerland)2025
Curcumin-QingDai combination for patients with active Crohn's disease: a retrospective, real-world multicenter cohort study.
Article in Frontiers in gastroenterology (Lausanne, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Diet and Gut Microbiota in Inflammatory Bowel Disease: A Clinical and Nutritional Perspective.Pharmaceuticals (Basel, Switzerland) · 2026Review
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9 authors.
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Abstract
Background: The combination of curcumin and QingDai (CurQD) promotes aryl hydrocarbon receptor (AhR) activation and is effective in ulcerative colitis; however, its benefit in Crohn's disease (CD) has not been studied. Methods: This is a retrospective, multicenter cohort study of patients who received CurQD for active CD, defined as the two-item patient-reported outcome (PRO2) stool frequency (SF) ≥ 2 and abdominal pain (AP) ≥ 1. The primary endpoint was the rate of clinical remission at the end of induction (weeks 8-12), defined by a PRO2 SF ≤ 1 and an AP = 0. The secondary endpoints included biomarker response [fecal calprotectin (FCP) drop ≥50% in a patient with FCP >250 μg/g at baseline] and remission (FCP drop ≥50% and FCP < 250 μg/g at the end of induction) and CurQD retention. Exploratory analysis of the public domain Genotype-Tissue Expression (GTEx) dataset was performed to elucidate the mRNA expression of AhR along the gut axis. Results: A total of 30 patients were identified for the safety dataset (13/30, 43% bio-experienced), and 25 were eligible for inclusion in the efficacy analysis. Clinical PRO2 remission at the end of induction was achieved in 12/25 (48%) patients and clinical response in 19/25 (76%), with an overall reduction in the median PRO2 score from 15 (95%CI = 13-19.7) to 4 (95%CI = 2-8.7, Conclusion: In this first-reported real-world experience, the AhR agonist CurQD was effective in inducing and maintaining the clinical and biomarker response and remission in over 50% of patients with CD, including in biologic-experienced patients.
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