Evidence map›Paper›PMID 41822250›Full record

ArticleCureus2026

A Rare Case of Levetiracetam-Induced Hemolytic Anemia.

Pedro D Gil de Rubio Cruz, Dorimar Morales Torres, Karolane A Gonzalez Gonzalez

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pedro D Gil de Rubio CruzDepartment of Internal Medicine, University of Puerto Rico at Río Piedras, San Juan, PRI.
Dorimar Morales TorresHealth Services Administration, Centro Comprensivo de Cáncer de la Universidad de Puerto Rico, San Juan, PRI.
Karolane A Gonzalez GonzalezDepartment of Medicine, Universidad Central del Caribe, Bayamón, PRI.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This is the case of a 77-year-old female patient with Alzheimer's disease, complicated by partial complex seizures. Levetiracetam was administered, which provoked hemolytic anemia. An extensive laboratory evaluation was suggestive of a non-immune etiology. Subsequent discontinuation of levetiracetam resulted in improvement of hemoglobin. Pancytopenia has been reported with the use of levetiracetam, but not isolated anemia. With this case report, we want to increase awareness of a potentially serious adverse reaction provoked by levetiracetam, a preferred anticonvulsive drug in the geriatric population.

Indexed as

alzheimer's disease and epilepsyanti-seizure medicationdrug induced adverse effectgeriatric pharmacologylevetiracetam-induced hemolytic anemia

Identifiers

PMID41822250
PMCPMC12978846

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.