Evidence map›Paper›PMID 41822152›Full record

ArticleArXiv2026

Assessing Hemodynamic Impact of Tissue-Engineered Vascular Graft Displacement: Combining Postoperative in vivo Results and Computational Modeling to Improve Surgical Planning.

Seda Aslan, Enze Chen, Miya Mese-Jones, Jacqueline Contento, Hidenori Hayashi, Keigo Kawaji, Joey Huddle, Jed Johnson, Yue-Hin Loke, Mark Fuge and 4 more

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Seda AslanDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Enze ChenDepartment of Civil and Systems Engineering, Johns Hopkins University, Baltimore, MD, USA.
Miya Mese-JonesDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Jacqueline ContentoDepartment of Cardiology, Children's National Hospital, Washington, DC, USA.
Hidenori HayashiDepartment of Surgery, Section of Cardiac Surgery, University of Chicago Medical Center, Chicago, IL, USA.
Keigo KawajiDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
Joey HuddleNanofiber Solutions, Dublin, OH, USA.
Jed JohnsonNanofiber Solutions, Dublin, OH, USA.
Yue-Hin LokeDepartment of Cardiology, Children's National Hospital, Washington, DC, USA.
Mark FugeDepartment of Mechanical Engineering, University of Maryland, College Park, MD, USA.
Laura OlivieriDepartment of Cardiology, Children's National Hospital, Washington, DC, USA.
Thao D NguyenDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Narutoshi HibinoDepartment of Surgery, Section of Cardiac Surgery, University of Chicago Medical Center, Chicago, IL, USA.
Axel KriegerDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.

Funding

Patient specific 3D printed tissue engineered vascular graft for aortic reconstruction designed by artificial intelligence algorithm.R01HL143468 · NHLBI · UNIVERSITY OF CHICAGO · PI FUGE, MARK, HIBINO, NARUTOSHI · 2018 to 2021
$2.7M
Patient Specific Tissue Engineered Vascular Graft Creation Using 3D Printing TechnologyR33HD090671 · NICHD · UNIVERSITY OF CHICAGO · PI HIBINO, NARUTOSHI, KRIEGER, AXEL · 2019 to 2021
$1.2M
MR Quantification of Myocardial Oxygen Utilization in Chronic Myocardial Infarction without ContrastK25HL141634 · NHLBI · ILLINOIS INSTITUTE OF TECHNOLOGY · PI KAWAJI, KEIGO · 2019 to 2023
$831k
Patient Specific Tissue Engineered Vascular Graft Creation Using 3D Printing TechnologyR21HD090671 · NICHD · JOHNS HOPKINS UNIVERSITY · PI HIBINO, NARUTOSHI, KRIEGER, AXEL · 2017 to 2018
$484k
NHLBI NIH HHS K25 HL141634NHLBI NIH HHS R01 HL143468NICHD NIH HHS R21 HD090671NICHD NIH HHS R33 HD090671
6 · The paper itself

Abstract

Purpose: Tissue-engineered vascular grafts (TEVG) have shown promise in advancing vascular reconstructions. However, precise in vivo implantation is challenging, and it is unclear how deviations in location and size affect hemodynamics. This study aims to 1) compare preoperative designs and postoperative anatomies of TEVG in an in vivo study to evaluate discrepancies and 2) investigate the impact of graft displacement and size on hemodynamics by virtually simulating implantation scenarios that are informed by in vivo postoperative results. Methods: Designed and postoperative geometries of four porcine aortas were compared to measure the mismatch in implantation location and graft shape. These results informed a virtual TEVG implantation study. TEVG location, orientation, and size were varied to investigate the effects on the final aorta shape and hemodynamics. Anastomosis of TEVG was simulated using finite element modeling. Key hemodynamic metrics were obtained from virtual implantations and actual postoperative anatomies using computational fluid dynamics. Results: Our in vivo study showed that TEVGs can experience up to 6.9 mm displacement and a 38° rotational shift post-implantation, leading to discrepancies in pressure drop (2.5 mmHg, 50%) and time-averaged wall shear stress (7.2 Pa, 72%) compared to predictions. Virtual TEVG implantation showed that peak systolic pressure drop (PSPD) was most sensitive to translation in the inferior-superior direction and rotation about the anterior-posterior axis. Size mismatch had a greater impact on time-averaged wall shear stress (TAWSS) (85%) than PSPD (23%). Additionally, virtual anastomosis simulations improved aortic shape predictions by 27.5%. Conclusion: Our results highlight the sensitivity of key hemodynamic metrics to graft implantation location and size mismatch. By quantifying displacement ranges and their impacts during surgery, surgeons can make informed decisions.

Indexed as

aorta repaircomputational fluid dynamicsfinite element modelingsurgical planningTissue-engineered vascular graft

Identifiers

PMID41822152
PMCPMC12976936

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.