ArticleFrontiers in microbiology2026
Genomic analysis of an extremophile PLS47 from a deep-sea vent.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Abstract
Indonesia's submarine hydrothermal vents represent underexplored ecosystems harboring thermophilic microbial diversity with significant biotechnological potential. In the study, the whole-genome sequencing, assembly, and comparative genomic analysis of strain PLS47, an extremophilic bacterium isolated from the Pria Laot hydrothermal vent, Sabang, Aceh, Indonesia is reported. The genome was sequenced using Oxford Nanopore Technology, assembled de novo, and polished to obtain a high-quality draft genome. Genome annotation identified genes associated with thermotolerance, stress response, and diverse metabolic pathways, including COG, KEGG, and CAZymes analysis. Comparative genomic analyses, including ANI and phylogenomic, confirmed its taxonomic placement and highlighted genomic distinctions from closely related terrestrial strains. Pangenome analysis further revealed unique gene sets potentially linked to adaptation to deep-sea hydrothermal environments. The complete genome sequence local isolate PLS47 is 3,772,236 bp at chromosomal genome with GC content at 52.02%, along with 56,806 bp at plasmid DNA with GC content at around 41.06%. A total of 3,708 coding sequences (CDSs) were identified, 6 rRNA (5S, 16S, and 23S), 27 rRNA, 88 tRNA genes, and 17 pseudogenes. A comparison of the genome to data based on Average Nucleotide Identity shows that the genome is closely related to the
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