ArticleBrain communications2026
Brain-injury and Alzheimer's disease biomarkers are elevated in patients with suspected infection and physiological derangement: importance for context-specific interpretation of Alzheimer's biomarkers.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Following acute infective illness, patients frequently exhibit neurological symptoms, with persistent neurological symptoms commonly observed following severe infection. However, the association between systemic infection and the concentration of blood-based biomarkers of brain injury and the relationship between these and markers of the host response to infection are poorly characterized in the literature. Further, the association between acute illness and the Alzheimer's disease-associated biomarker phosphorylated-tau-217 (p-tau-217) is unknown. In acute samples from 26 patients attending the emergency department with suspected sepsis (clinically suspected or proven infection, a National Early Warning Score or National Early Warning Score 2 score ≥ 5), the levels of serum biomarkers of brain injury (neurofilament light [NfL], glial fibrillary acidic protein (GFAP), total tau and ubiquitin C-terminal hydrolase L1) and p-tau-217 were compared to age- and sex-matched non-infected controls, with further assessment of the correlation between the biomarker levels and cytokine profiles. p-tau-217 levels were additionally compared to a positive control group of patients with diagnosed Alzheimer's disease. Both total tau (
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