Evidence map›Paper›PMID 41821950›Full record

ArticleSymbiosis (Philadelphia, Pa.)2025

A review of the venom microbiome and its utility in ecology and evolution including future directions for emerging research.

Marina E De León, Eduardo G P Fox, Sara Dunaj, Ronald A Jenner, Carl N Keiser, Jason Macrander, Samantha A Nixon, Clarissa J Nobile, Daniel Petras, Eduardo Rodriguez-Roman and 7 more

Abstract read
In one paragraph

Article in Symbiosis (Philadelphia, Pa.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marina E De LeónUniversity of California Davis, Genome Center, 451 Health Sciences Drive, Davis, CA 95616, USA.ORCID 0000-0001-9973-1951
Eduardo G P FoxPrograma de Pós-Graduação em Ambiente e Sociedade (PPGAS), Universidade Estadual de Goiás (UEG), Avenida Brasil 435, Quirinópolis GO 75864-970, Brazil.ORCID 0000-0001-6141-255X
Sara DunajDepartment of Biological Sciences, University of Massachusetts Lowell, Lowell, MA, USA.ORCID 0000-0002-2623-7327
Ronald A JennerNatural History Museum, Cromwell Road, London SW7 5BD, UK.ORCID 0000-0002-3297-2408
Carl N KeiserDepartment of Biology, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0002-4936-7810
Jason MacranderDepartment of Biology, Florida Southern College, 111 Lake Hollingsworth Drive, Lakeland, FL 33801, USA.ORCID 0000-0002-1509-4332
Samantha A NixonCardiovascular Research Institute, University of California, San Francisco, 525 Mission Bay Boulevard, San Francisco, CA 94158, USA.ORCID 0000-0003-3157-4114
Clarissa J NobileDepartment of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, 5200 North Lake Road, Merced, CA 95343, USA.ORCID 0000-0003-0799-6499
Daniel PetrasDepartment of Biochemistry, University of California Riverside, Riverside, CA, USA.ORCID 0000-0002-6561-3022
Eduardo Rodriguez-RomanCenter for Microbiology and Cell Biology, Instituto Venezolano de Investigaciones Cientificas, Caracas 1020A, Venezuela.ORCID 0000-0001-8717-7527
Anthony J SaviolaDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, 12801 East 17Th Avenue, Aurora, CO, USA.ORCID 0000-0001-6890-512X
Steven A TrimVenomtech Ltd, Discovery Park, Sandwich, Kent CT13 9FE, UK.ORCID 0000-0002-3524-4115
Natascha S VaronaBiology Department, University of Miami, 1301 Memorial Dr, Coral Gables, FL 33133, USA.ORCID 0000-0001-8783-3301
Justin YeagerFacultad de Ingenierías y Ciencias Aplicadas, Grupo de Biodiversidad Medio Ambiente y Salud, Universidad de Las Américas, Quito, Ecuador.ORCID 0000-0001-8692-6311
Sabah Ul-HasanHologic, Inc, San Diego, CA, USA.ORCID 0000-0001-6334-452X
Volker HerzigCentre for Bioinnovation, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia.ORCID 0000-0003-2514-3983
Timothy J ColstonDepartment of Biology, University of Puerto Rico at Mayagüez, Call Box 9000, Mayagüez, Puerto Rico 00681.ORCID 0000-0002-1127-1207

Funding

Genetic regulation of inter- and intra-species microbial community formationR35GM124594 · NIGMS · UNIVERSITY OF CALIFORNIA, MERCED · PI NOBILE, CLARISSA JANE · 2017 to 2021
$2.0M
NIGMS NIH HHS R35 GM124594
6 · The paper itself

Abstract

Microbes play vital roles in ecological systems, yet their presence and functions within venom environments of venomous organisms remain understudied. Despite the prevalent belief in the sterility of venoms, recent findings reveal diverse microbial communities within venom systems. This review aims to explore the relationships between venoms and microbes, highlighting their potential roles in evolutionary processes, ecological interactions, and therapeutic advancements. Venoms, composed of toxins utilized in hunting or defense, represent a rich source of natural products with applications in drug discovery and therapy, exemplified by FDA-approved venom toxin-derived drugs. Understanding microbial resistance mechanisms against antimicrobial peptides can illuminate coevolutionary processes and guide therapeutic development. Integrating hologenomic evolution and microbial ecology frameworks will facilitate comprehensive research on venom-microbiome interactions, and reveal the evolutionary drivers of venom diversification. Investigating and investing in these relationships promises advancements in understanding evolution, ecology, and biotechnology, with implications for human health and ecological conservation. This review synthesizes existing knowledge, identifies many gaps in literature, and investigates critical unanswered questions in the field of venom microbiology, encouraging ongoing and future collaborative research.

Indexed as

BacteriaHost-microbiomeNatural ProductsOmicsSymbiosisVenom

Identifiers

PMID41821950
PMCPMC12978238

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.