ArticleFrontiers in neuroscience2026
Electroacupuncture ameliorates chronic heart failure: the role of CRH neurons in the paraventricularnucleus of the hypothalamus.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic heart failure (CHF) constitutes the terminal stage of ischemic heart disease and is characterized by a high mortality rate. Our previous studies have demonstrated that electroacupuncture (EA) modulates the paraventricular nucleus (PVN) of the hypothalamus, thereby exerting a cardioprotective effect against myocardial ischemia. However, the specific mechanisms underlying the role of corticotropin-releasing hormone (CRH) neurons, which are critical for regulating sympathetic outflow and stress responses within the PVN, remain unclear in the context of CHF. Additionally, CHF has been proven to cause an imbalance in the autonomic nervous system. This study seeks to investigate whether EA can re-establish cardiac autonomic homeostasis and ameliorate CHF by modulating PVN Methods: The CHF rat model was established via permanent ligation of the left anterior descending coronary artery. Subsequently, EA was administered at the HT7 ( Results: This study indicated that EA significantly ameliorated CHF. In the CHF rat model, we observed excessive activation of the sympathetic nervous system, concomitant with an increased number of c-Fos-positive neurons in the PVN. EA intervention effectively reversed these changes. Viral tracing revealed neural connections between the heart, HT7 acupoint, and PVN. Following lesioning of the PVN, the therapeutic efficacy of EA was attenuated. Furthermore, chemogenetic experiments revealed that inhibiting the activity of PVN Conclusion: EA ameliorated CHF by inhibiting the activity of PVN
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