ArticleImaging neuroscience (Cambridge, Mass.)
Brain patterns linked to neuropsychiatric genetic risk mirror those seen in disease.
Article in Imaging neuroscience (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Analyzing brain morphological changes across individuals with varying genetic risk scores may reveal patterns of brain alterations from health to disease. This study investigates gray matter structural alterations in individuals with clinical diagnoses compared with those with genetic risk alone. UK Biobank MRI and genotypes (N = 34,720) were used to derive brain measures and polygenic risk scores, creating genetic risk brain maps for 14 neuropsychiatric disorders. Eight disorders from ENIGMA were used to construct disease brain maps. Brain maps of genetic risk and clinical diagnosis show overall alignment for ADHD, schizophrenia, bipolar disorder, and autism. Other conditions, including Alzheimer's disease, show specific brain regions linked to genetic risk aligning with established patient patterns. Incomplete data for some conditions limit analyses. ADHD and PTSD polygenic burden was associated with smaller global brain sizes, while Parkinson's disease was linked to larger brain volume. Mendelian randomization analyses revealed unidirectional relationships where the brain influences ADHD and Parkinson's disease, while a bidirectional causal association was observed for schizophrenia. Focusing on schizophrenia and bipolar disorder, we found that individuals with high genetic risk combined with smaller brain structures were more likely to have these diagnoses. Overall, the study demonstrates marked similarities in brain changes between clinical diagnoses and genetic risk for several disorders, albeit with mild effect sizes in the latter. These findings underscore the importance of genetic risk in influencing brain anatomy and the progression of neuropsychiatric disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.