ArticleJournal of medical biochemistry2026
Diagnostic value of mucosal-associated invariant T+ cells combined with inflammatory factors in differentiating chronic rhinosinusitis subtypes with or without nasal polyps.
Article in Journal of medical biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The present study attempted to analyze the effect of mucosal-associated invariant T (MAIT) combined with inflammatory factors in identifying chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP) that provides a clinical reference. Methods: In this retrospective study, we enrolled 56 CRSsNP patients, 68 CRSwNP patients, and 64 healthy controls. Flow cytometry was used to detect the frequency of peripheral blood MAIT+ cells (MAIT+). Serum levels of hs-CRP, IL-ip, and IL-6 were measured by ELISA and automatic blood cell analyzer, and their correlations with MAIT cell alterations were analyzed. The diagnostic effect of MAIT+ combined with hs-CRP IL-ip, and IL-6 on CRS was analyzed using ROC curves. Results: Both CRSsNP and CRSwNP patients exhibited significantly reduced MAIT+ frequencies compared to controls (P< 0.05), with CRSwNP showing the most pronounced decrease (P < 0.0 5). MAIT+ frequency was inversely correlated with hs-CRP IL-ip, and IL-6 in CRS patients. ROC analysis demonstrated that MAIT+ effectively discriminated CRSsNP (AU C= 0.793) and CRSwNP (AU C= 0.863) from healthy individuals (P< 0.01). After combined with inflammatory factors, the diagnostic effect of MAIT+ combined inflammatory factors on CRSsNP (AU C= 0.933) and CRSwNP (AU C= 0.939) was further improved. Conclusions: Detection of MAIT+ combined with inflammatory factors may provide potential biomarkers for CRS subtype identification.
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