ReviewBiomedical reports2026
Histone lactylation modification and its role in cerebral ischemia-reperfusion injury (Review).
Review in Biomedical reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral ischemia-reperfusion injury (CIRI), a major condition that poses a considerable threat to human health, has high incidence, disability and mortality rates. Mitigating brain damage during reperfusion has been the focal point of research due to the complex physiological and pathological changes that occur during this process. Histone lactylation has garnered considerable attention from researchers as a novel post-translational modification. Lactate, a metabolic byproduct, regulates gene transcription through histone lactylation, thereby linking cellular metabolism to gene expression programs and contributing to the development of diverse diseases. The present review comprehensively discusses the mechanisms underlying histone lactylation in CIRI and explores its potential clinical applications. The present review aims to offer an understanding of the role of lactylation in CIRI to facilitate the development of novel therapeutic strategies and drugs, and to offer novel insights and directions for the prevention and treatment of CIRI.
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