ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Cerebrospinal fluid sclerostin levels in the early Alzheimer's disease stages.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Elevated sclerostin levels in cerebrospinal fluid are associated with cognitive impairment in the Alzheimer's disease continuum.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Cerebrospinal fluid sclerostin levels in the early Alzheimer's disease stages.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
15 authors.
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Abstract
introductionSclerostin, a negative regulator of bone formation, has been involved in memory impairment in Alzheimer's disease (AD) mouse models and is increased in elderly people at risk of AD. Here, we investigated sclerostin's role across the clinical stages of AD.
methodsWe evaluated cerebrospinal fluid (CSF) sclerostin levels in patients with dementia due to AD, mild cognitive impairment, and subjective memory complaints, biologically characterized via the amyloid/tau/neurodegeneration classification. Results were correlated with AD biomarkers, amyloid beta (Aβ) 42, phosphorylated tau (p-tau), and total tau (t-tau), and clinical parameters of dementia severity.
resultsCSF sclerostin increased in patients with dementia due to AD and correlated negatively with Aβ42 and positively with p-tau, t-tau, and dementia severity. DISCUSSION: The association of CSF sclerostin with Aβ42, tau pathology, and dementia severity in the early disease stages is of great clinical relevance for the identification of sclerostin as a promising biomarker in early AD stages.
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