Trial reportFrontiers in endocrinology2026
Efficacy and safety of Dysmenorrhea Patch acupoint application in women with primary dysmenorrhea: a randomized double-blind controlled trial.
Trial report in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Primary dysmenorrhea (PD) is defined as pain occurring with menses in the absence of pelvic pathology. Traditional Chinese Medicine offers various therapeutic approaches for PD management. Dysmenorrhea Patch, an acupoint application therapy, shows promise for PD management, but its clinical efficacy and safety require further evaluation. This study aimed to assess the efficacy and safety of the Dysmenorrhea Patch in PD. Methods: This multicenter, randomized, double-blind, placebo-controlled trial was conducted at outpatient clinics in Shanghai, China. Recruitment period: May 2021 through October 2024. Women aged 18-40 years with primary dysmenorrhea were randomized 1:1 to receive the Dysmenorrhea Patch (acupoint application patch) or a placebo patch for three consecutive menstrual cycles. Patches were applied to predefined acupoints for 8 hours daily during the non-menstrual phase of each cycle and withheld during menstruation. The primary endpoint was total effective rate (TER) based on the percentage reduction in Numerical Rating Scale (NRS) scores. Secondary endpoints included NRS, Cox Menstrual Symptom Scale (CMSS), Traditional Chinese Medicine (TCM) syndrome score, serum Prostaglandin F2α (PGF2α) and Prostaglandin E2 (PGE2), rescue ibuprofen use, and safety outcomes (local skin reactions and serum alanine aminotransferase [ALT]). Results: Of 110 randomized participants, 102 participants completed the end-of-treatment assessment. After three cycles, TER was significantly higher in the intervention group than the control group (60.00% vs. 34.55%, Conclusion: Dysmenorrhea Patch acupoint application for three menstrual cycles improved clinical response and reduced pain intensity and symptom burden in women with Qi stagnation and blood stasis type PD, with favorable prostaglandin changes and good safety. Larger and longer-term studies with rigorous assessment of blinding and concomitant medication effects are warranted. Clinical Trial Registration: https://www.chictr.org.cn/showprojEN.html?proj=60256, identifier ChiCTR2000037102.
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