ArticleMediterranean journal of hematology and infectious diseases2026
Effect of Fresh versus Cryopreserved Grafts on Febrile Neutropenia and Infections in Allogeneic Hematopoietic Cell Transplantation: Factors Determining Mortality.
Article in Mediterranean journal of hematology and infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The study aimed to compare the incidence and course of febrile neutropenia (FN) and factors affecting mortality in hematologic patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) with either fresh or cryopreserved grafts. Methods: The clinical data of 155 patients who underwent allo-HSCT at our hematology clinic between 2010 and 2023 were retrospectively analyzed. The incidence of bloodstream infection (BSI) and FN-related mortality was analyzed in these patients. Factors affecting FN-related mortality were examined using a logistic regression model. Results: A total of 143 patients who developed FN were included in the study. Ninety-eight patients underwent transplantation with fresh stem cells, and 45 patients with cryopreserved stem cells. The duration of FN episodes was similar between groups (p = 0.077); however, the duration of deep neutropenia (neutrophils < 100/mm Conclusions: This study demonstrated that, regardless of graft type, prolonged FN duration and a high HCT-CI score are the primary determinants of mortality. Therefore, clinical management of patients should also address these risk factors.
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