Evidence map›Paper›PMID 41821551›Full record

ArticleFrontiers in genetics2025

Prognosis of pediatric restrictive cardiomyopathy: more severe in sarcomeric variants.

Catherine Gardin, Pierre-Emmanuel Michels, Elena Panaioli, Elise Daire, Flavie Ader, Sophie Malekzadeh-Milani, Damien Bonnet, Diala Khraiche

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In one paragraph

Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Catherine GardinPediatric Cardiology and Pediatric Intensive Care Unit, Angers University Hospital, Angers, France.
Pierre-Emmanuel MichelsPsychiatric Department, Angers University Hospital, Angers, France.
Elena PanaioliM3C-Necker, Congenital and Pediatric Cardiology Department, Necker Hospital-Enfants Malades University Hospital, Paris, France.
Elise DairePediatric Cardiology Department, Amiens University Hospital & Laboratory EA4666 Hematim, University of Picardie-Jules Verne, Amiens, France.
Flavie AderSorbonne Université-DMU BioGem-Unité Fonctionnelle de Cardiogénétique et Myogénétique Moléculaire et cellulaire, Service de Biochimie Métabolique, APHP-Hôpital Universitaire Pitié Salpêtrière, Paris, France.
Sophie Malekzadeh-MilaniM3C-Necker, Congenital and Pediatric Cardiology Department, Necker Hospital-Enfants Malades University Hospital, Paris, France.
Damien BonnetM3C-Necker, Congenital and Pediatric Cardiology Department, Necker Hospital-Enfants Malades University Hospital, Paris, France.
Diala KhraicheM3C-Necker, Congenital and Pediatric Cardiology Department, Necker Hospital-Enfants Malades University Hospital, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Restrictive cardiomyopathy (RCM) is the most severe type of cardiomyopathy in children with a very poor prognosis. RCM is often diagnosed between 6 and 10 years old and is predominantly of genetic origin. We conducted a retrospective study of 53 patients. The aim of our study was to determine whether outcomes are associated with the type of genetic variant. We compared the prognosis of patients with sarcomeric variants (n = 26) to those with non sarcomeric variants (n = 27). Our results showed no significant differences between the two groups at diagnosis in terms of heart failure symptoms, NT-proBNP levels, or hemodynamic parameters. However, survival without transplantation was significantly worse in the sarcomeric group (p = 0.003), which also exhibited greater disease severity. Furthermore, thrombotic events were more frequent in the sarcomeric group (p = 0.05). In conclusion, RCM caused by sarcomeric variants is associated with a poorer prognosis and a higher incidence of thrombotic events compared to non-sarcomeric RCM.

Indexed as

cardiomyopathyheart transplantationpediatricrestrictive cardiomyopathysarcomeric

Identifiers

PMID41821551
PMCPMC12978873

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.