ReviewCell proliferation2026
Mechanobiology in Stem Cell-Based Bioprinting.
Review in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Bioprinting with stem cells is an emerging technique for creating human tissues from scratch, transforming our understanding of biology and its biomedical applications. While significant attention has been paid to biochemical cues, mechanobiology is emerging as an equally important regulator in stem cell-based bioprinting, yet it has long been unexplored. Recent advances in elucidating mechanotransduction pathways underscore the need to comprehend bioink mechanics to bridge printability and stem cell fate regulation. This review emphasises the central role of mechanobiology in stem cell-based bioprinting: ensuring adequate printability while maintaining and programming stem cell functionality through biomechanical signals. We discuss how the mechanical properties of bioinks influence stem cell behaviour, with a focus on mechanosensitive stem cells, including pluripotent, mesenchymal, neural, hepatic and lung stem cells. Special attention is given to stem cell-based organoids and their associated mechanotransduction signalling pathways. We further identify four key mechanobiological requirements that define the relationship between print fidelity and the mechanical cues governing stem cell mechanosensing. We propose integrative strategies drawing from innovations in materials science and bioprinting to reframe mechanics as a tunable parameter rather than a constraint. Our roadmap aims to leverage bioink mechanics not only to facilitate biofabrication but also to guide stem cell fate and functional remodelling of engineered tissues for potential clinical applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.