Evidence map›Paper›PMID 41821384›Full record

ReviewBioMed research international2026

Global Research Trends on Endothelial Glycocalyx in Sepsis: A Bibliometric Analysis.

Kamila R Daniyarova, Zhanslu N Sarkulova, Amin Tamadon, Ainur B Tokshilykova, Marat N Sarkulov, Botagoz M Kalieva, Nadiar M Mussin, Ramazon Safarzoda Sharoffidin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kamila R DaniyarovaDepartment of Anesthesiology and Reanimatology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.ORCID https://orcid.org/0000-0002-6145-1839
Zhanslu N SarkulovaDepartment of Anesthesiology and Reanimatology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.ORCID https://orcid.org/0000-0001-6669-1244
Amin TamadonDepartment of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.ORCID https://orcid.org/0000-0002-0222-3035
Ainur B TokshilykovaDepartment of Anesthesiology and Reanimatology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.ORCID https://orcid.org/0000-0003-4416-0180
Marat N SarkulovDepartment of Surgical Diseases No.2 With a Course in Urology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.ORCID https://orcid.org/0000-0003-1165-9049
Botagoz M KalievaDepartment of Anesthesiology and Reanimatology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.ORCID https://orcid.org/0000-0001-7343-0528
Nadiar M MussinDepartment of Surgery No. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.ORCID https://orcid.org/0000-0003-3600-8840
Ramazon Safarzoda SharoffidinDepartment of Pharmaceutical Technology, Avicenna Tajik State Medical University, Dushanbe, Tajikistan, tajmedun.tj.ORCID https://orcid.org/0000-0001-9304-6945

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSepsis remains a major global health challenge, with glycocalyx dysfunction playing an important role in its pathogenesis. Recent research highlights EG degradation as a key contributor to vascular permeability, inflammation, and organ failure. Despite growing interest, a comprehensive bibliometric analysis of global research trends on EG in sepsis is lacking.

methodsWe conducted a bibliometric analysis using data from Web of Science and Scopus (2005-2025). Inclusion criteria were original English-language research articles. Bibliometrix R-package was employed to analyze publication trends, citation metrics, collaboration networks, and keyword co-occurrence.

resultsAmong 217 publications, research output increased 13-fold (2005-2023), with Shock and Critical Care as leading journals. The United States, Japan, and Australia were top contributors, with strong international collaborations. Key themes included EG biomarkers, microcirculatory dysfunction, and therapeutic strategies. Emerging trends involved COVID-19-associated EG injury and novel imaging techniques.

conclusionThis study maps the evolution of EG research in sepsis, highlighting exponential growth, key contributors, and thematic shifts. Future directions include validating EG biomarkers, developing targeted therapies, and enhancing global research equity.

Indexed as

BibliometricsBiomedical ResearchGlycocalyxSepsisBiomarkersCOVID-19HumansMicrocirculationSARS-CoV-2Biomarkersbibliometricsglycocalyxmicrocirculationsepsissyndecan-1

Identifiers

PMID41821384
PMCPMC13140797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.