Evidence map›Paper›PMID 41821321›Full record

ArticleInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2026

Injectable radiopaque targets for cone-beam CT guided histotripsy.

Katrina L Falk, Michael A Speidel, Grace M Minesinger, Gretchen M Foltz, Fred T Lee, Timothy J Ziemlewicz, Martin G Wagner, Paul F Laeseke

Abstract read
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In one paragraph

Article in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katrina L FalkDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.ORCID 0000-0001-7646-2541
Michael A SpeidelDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.
Grace M MinesingerDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.
Gretchen M FoltzDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.
Fred T LeeDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.
Timothy J ZiemlewiczDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.
Martin G WagnerDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.
Paul F LaesekeDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.

Funding

U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Advanced multimodal image-guided histotripsy for precise, safe and effective histotripsy of liver tumorsR01EB031007 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI Paul F Laeseke, Martin Gerd Wagner · 2022 to 2026
$2.5M
Developing an Accurate and Robust Targeting Technique to Enable Transcostal Histotripsy Treatment of Liver TumorsF30CA284541 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Katrina Lauren Falk · 2024 to 2026
$135k
NCI NIH HHS F30 CA284541NCI NIH HHS T32 CA009206NIBIB NIH HHS R01 EB031007NIGMS NIH HHS T32 GM140935
6 · The paper itself

Abstract

backgroundCone-beam CT (CBCT) guided histotripsy is being developed as a supplemental image guidance technique for histotripsy. The goal of this work is to present a percutaneously injectable, radiopaque target that can be used in preclinical testing of CBCT-guided histotripsy.

methodsLivers of five

resultsThere was no significant difference in imaged volume or intensity between the 100 or 200 µL(

conclusionPercutaneously injectable, radiopaque barium-based targets were acutely safe, targetable and treatable on CBCT and did not alter histotripsy treatment zone size

Indexed as

Cone-Beam Computed TomographyContrast MediaLiverAnimalsSwineContrast Mediabariumcone-beam CTHistotripsyinjectionpreclinicalswine

Identifiers

PMID41821321
PMCPMC13072709

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.