ArticleJournal of clinical apheresis2026
Effects of Immunoadsorption on Markers of Iron Metabolism: A Case Series.
Article in Journal of clinical apheresis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Immunoadsorption selectively eliminates circulating antibodies in antibody-mediated diseases. Iron deficiency is the most common cause of anemia; however, the potential role of immunoadsorption in contributing to iron depletion remains insufficiently established. This study quantified levels of eluted iron, ferritin, and transferrin in the regeneration solutions of peptide ligand adsorbers from 13 patients and in ABO antigen-specific non-regenerative adsorbers from five patients. Markers of anemia and iron status were assessed at baseline and monitored for up to 2 weeks. Analysis of regeneration solutions from regenerative adsorbers revealed considerable levels of eluted iron (5.46 ± 7.4 μg/dL in NaCl 0.9%; 1.46 ± 1.45 μg/dL in glycine, and 3.61 ± 6.07 μg/dL in PBS), ferritin (52.65 ± 96.14 ng/mL in NaCl 0.9%; 18.79 ± 46.44 ng/mL in glycine and 4.93 ± 14.79 ng/mL in PBS), and transferrin (0.168 ± 0.26 g/L in NaCl 0.9%; 0.594 ± 2.37 g/L in glycine, and 0.005 ± 0.02 g/L in PBS). In ABO adsorbers, 50.27 ± 22.66 μg/dL iron, 88.39 ± 33.21 ng/mL ferritin, and 1.165 ± 0.41 g/L transferrin were detected, implicating adsorbers to directly deplete iron-related proteins. Blood hemoglobin (-1.88 g/dL), erythrocyte count (-0.58 × 10
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