Evidence map›Paper›PMID 41821224›Full record

ArticleEwha medical journal2026

Nociceptive pain as a clinical presentation of chronic urticaria and disappearance with immunoglobulin/histamine complex therapy: a case report.

Hyuk Soon Kim, Dae Hwan Kim, Yunyoung Nam, Jeong Eun Sohn, Geunwoong Noh

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Ewha medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hyuk Soon KimDepartment of Biomedical Sciences, College of Natural Science, Dong-A University, Busan, Korea.
Dae Hwan KimDepartment of Anesthesiology, Cheju Halla General Hospital, Jeju, Korea.
Yunyoung NamDepartment of Anesthesiology, Cheju Halla General Hospital, Jeju, Korea.
Jeong Eun SohnDepartment of Anesthesiology, Cheju Halla General Hospital, Jeju, Korea.
Geunwoong NohDepartment of Allergy and Clinical Immunology, Cheju Halla General Hospital, Jeju, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Itching is a representative manifestation of urticaria. However, under certain conditions, urticaria may be characterized by nociceptive sensations, such as stinging or tingling, either instead of or in addition to itching. Three patients with chronic urticaria (CU) who experienced nociceptive pain accompanied by itching were identified and treated with immunoglobulin/histamine complex (IHC) therapy. Nociceptive pain resolved along with improvement in CU symptoms after 8 injections of IHC in the first patient and after 4 injections in the second and third patients. Nociceptive pain may present as a symptom of CU. The clinical characteristics of the transition from itching to nociceptive pain, together with the observed outcomes of IHC therapy, appear to support the intensity theory explaining this shift, which may be mediated by histamine. Further clinical and basic immunological studies are warranted to clarify the underlying mechanisms.

Indexed as

Case reportsChronic urticariaHistamineImmunoglobulinNociceptive pain

Identifiers

PMID41821224
PMCPMC13149945

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.