Evidence map›Paper›PMID 41821182›Full record

ArticleCancer biology & medicine2026

Mitochondrial uncoupling inhibits serine catabolism

Xin Jin, Albert M Li, Man Zhao, Haowen Jiang, Yiren Xiao, Michaela Yip, Stavros Melemenidis, Scott Jackson, Yanan Yang, Cathyrin Simmermaker and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xin Jin *Department of Oncology and Hematology, The Second Hospital of Jilin University, Changchun, Jilin 130000, China.
Albert M Li *Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Man Zhao *Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Haowen JiangDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Yiren XiaoDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michaela YipDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stavros MelemenidisDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Scott JacksonDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Yanan YangAgilent Technologies, Santa Clara, CA 95051, USA.
Cathyrin SimmermakerAgilent Technologies, Santa Clara, CA 95051, USA.
Meng-Ning ZhouDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Subarna SinhaDepartment of Computer Science, Stanford University, Stanford, CA 94305, USA.
Daniel J CuthbertsonAgilent Technologies, Santa Clara, CA 95051, USA.
Erinn B RankinDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-2045-2296
Jiangbin YeDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-1117-4869

Funding

Agilent University Relations SIRA program #4792American Cancer Society Research Scholar RSG-20-036-01Stanford Maternal and Child Health Research Institute Faculty Scholar Award 2020
6 · The paper itself

Abstract

objectiveThe mitochondrial serine catabolic pathway (MSCP) supports tumor proliferation and metastasis, yet no therapies target the MSCP. Because cancer cells rely on the MSCP when respiration is suppressed, we hypothesized that reactivating respiration would inhibit the MSCP.

methodsMitochondrial respiration was activated in triple negative breast cancer (TNBC) cells using uncouplers [niclosamide ethanolamine (NEN) and BAM15]. Metabolic activity through the MSCP was assessed using U-

resultsActivation of mitochondrial respiration with NEN or BAM15 inhibited MSCP activity, as indicated by reduced labeling of glycine and purines from U-

conclusionsThe findings herein demonstrated that mitochondrial uncouplers inhibit MSCP through FTO-dependent m

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOBreast NeoplasmsMitochondriaSerineAminohydrolasesAnimalsCell Line, TumorFemaleFormate-Tetrahydrofolate LigaseGlycine HydroxymethyltransferaseHumansMetabolic ReprogrammingMethylenetetrahydrofolate Dehydrogenase (NADP)MiceMinor Histocompatibility AntigensMultienzyme ComplexesAlpha-Ketoglutarate-Dependent Dioxygenase FTOAminohydrolasesFormate-Tetrahydrofolate Ligaseformyl-methenyl-methylenetetrahydrofolate synthetaseFTO protein, humanGlycine HydroxymethyltransferaseMethylenetetrahydrofolate Dehydrogenase (NADP)Minor Histocompatibility AntigensMTHFD2 protein, humanMultienzyme ComplexesMultifunctional EnzymesSerineSHMT protein, humanbreast cancerFTOmmetastasisMitochondria uncouplerone-carbon unit metabolismserine catabolism

Identifiers

PMID41821182
PMCPMC13617950

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.