Evidence map›Paper›PMID 41821180›Full record

ReviewAnnals of medicine2026

'The good idea': a commentary on a decade of barbed sutures in cesarean surgery.

Maria Grazia Centurioni, Fabio Barra, Francesca Olcese, Claudio Gustavino, Simone Ferrero, Franco Alessandri

Abstract readReview
In one paragraph

Review in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maria Grazia CenturioniUnit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID 0000-0002-6813-7041
Fabio BarraUnit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID 0000-0003-4117-6603
Francesca OlceseAcademic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Claudio GustavinoUnit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID 0000-0001-7835-9441
Simone FerreroAcademic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID 0000-0003-2225-5568
Franco AlessandriUnit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID 0000-0003-3773-991X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMinimalist cesarean techniques have delivered clear perioperative benefits, including shorter procedures, reduced tissue dissection, and reproducibility across diverse settings. As cesarean rates rise, however, an important blind spot has emergedhow the uterine scar evolves over months and years.

objectiveTo provide a narrative synthesis and methodological perspective on uterine scar healing after cesarean delivery, with particular attention to surgical determinants of lower uterine segment integrity and the emerging role of barbed sutures. CONTENT: Post-cesarean niches and reduced residual myometrial thickness (RMT) are increasingly recognized as clinically relevant findings associated with abnormal bleeding, pelvic pain, subfertility, and difficult repeat surgery. Recently standardized ultrasonographic definitions allow these features to be measured reproducibly and compared across centers. Although evidence remains limited and heterogeneous, surgical factors influencing perfusion, tissue alignment, and tension distribution - shaped in part by suture material and closure technique - appear plausibly linked to long-term scar remodeling. Barbed sutures have gained interest because their knotless design distributes tension evenly and may help preserve perfusion and uniform coaptation. Comparative studies have reported associations between double-layer barbed closure and favorable imaging surrogates, such as thicker RMT and fewer or smaller niches, without apparent compromise in operative safety or efficiency. Evidence regarding subsequent pregnancy outcomes remains preliminary.

conclusionsCurrent signals regarding barbed sutures should be interpreted cautiously and underscore the need for methodologically rigorous investigations centered on uterine healing rather than operative speed alone. Future studies should incorporate standardized transvaginal ultrasound within one to two years after delivery, harmonized reporting of niche morphology and RMT, blinded image assessment, and predefined consideration of center and surgeon effects. Within this framework, double-layer barbed closure represents a plausible but provisional option whose clinical value requires confirmation through adequately powered multicenter research.

Indexed as

Cesarean SectionCicatrixSuturesSuture TechniquesUterusFemaleHumansMyometriumPregnancyUltrasonographyWound Healingbarbed sutureCesarean sectionfish-bone sutureplacenta accreta spectrumultrasounduterine nicheuterine scaruterine scar disorders

Identifiers

PMID41821180
PMCPMC12990264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.