ArticleChinese neurosurgical journal2026
Alteration of functional connectivity and network properties after stereo-electroencephalography guided radiofrequency thermocoagulation.
Article in Chinese neurosurgical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundStereo-electroencephalography guided radiofrequency thermocoagulation (RF-TC) aims at changing epileptogenic networks to achieve therapeutic purpose. However, the functional connectivity mechanism of RF-TC remains unknown. We sought to determine the effects of RF-TC on functional connectivity and the relationship between these variations and the clinical outcome.
methodsFor this retrospective cohort study, we analyzed resting-state stereoelectroencephalography (SEEG) data segments to assess functional connectivity across sampling areas in seventeen epilepsy patients. We analyzed the variance of functional connectivity and graph theory indicators and assessed the relationship between variation and clinical response to RF-TC.
resultsWe found decreased functional connectivity both within and between epileptogenic zone in alpha band (p < 0.05) after RF-TC. We also discovered the alteration of most graph theory properties in the alpha band. Moreover, within connectivity and betweenness were significantly decreased in alpha band in the non-improvement group (p < 0.05), while clustering coefficient showed opposite change in the improvement group (p < 0.05). Eventually, compared to improvement group, we discovered a greater decrease of within connectivity of alpha band in the epileptogenic zone (p < 0.01).
conclusionThe research on network changes after radiofrequency thermocoagulation (RF-TC) is still an evolving field. Our research results indicate that significant changes occurred in functional connectivity and network characteristics in specific frequency bands and brain regions after RF-TC. Notably, the reduction in the internal connectivity within the alpha frequency band of the epileptic lesion not only provides early electrophysiological feedback for RF-TC, but also serves as a potential indicator for evaluating clinical response and prognosis.
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