Evidence map›Paper›PMID 41821096›Full record

ArticleCell communication and signaling : CCS2026

Hsp70s regulate circadian rhythm by interacting with PERIOD.

Xianguo Zhao, Pengfei Lv, Yuansheng Huang, Yifan Zhang, Xiaoyu Wu, Xingzhuo Yang, Juan Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xianguo Zhao *Department of entomology, College of Plant Protection, State Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, China Agricultural University, Beijing, 100193, China.
Pengfei Lv *Department of entomology, College of Plant Protection, State Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, China Agricultural University, Beijing, 100193, China.
Yuansheng HuangDepartment of entomology, College of Plant Protection, State Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, China Agricultural University, Beijing, 100193, China.
Yifan ZhangDepartment of entomology, College of Plant Protection, State Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, China Agricultural University, Beijing, 100193, China.
Xiaoyu WuDepartment of entomology, College of Plant Protection, State Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, China Agricultural University, Beijing, 100193, China.
Xingzhuo YangDepartment of entomology, College of Plant Protection, State Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, China Agricultural University, Beijing, 100193, China.
Juan DuDepartment of entomology, College of Plant Protection, State Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, China Agricultural University, Beijing, 100193, China. dujuan9981@cau.edu.cn.

Funding

China Postdoctoral Science Foundation 2023M733793National Natural Science Foundation of China 32122017
6 · The paper itself

Abstract

Circadian rhythms synchronize life with the environment. Although the molecular feedback loop underlying these rhythms has been well-characterized, our understanding of cellular clocks remains incomplete. In this study, by applying cellular and biochemistry approaches, we reveal the involvement of Hsp70 family proteins in regulating the core clock feedback loop by modulating the condensation formation of the PERIOD (PER) protein. Mutations in Hsp70s lead to circadian rhythm defects in a temperature-dependent manner. Further mechanistic investigation uncovered that Hsp70s compete with TIM for binding to PER. Notably, Hsp70s are essential for reducing PER liquid condensates. By generating a complete null allele of per, we demonstrated that per functions downstream of Hsp70s. Our findings on the role of Hsp70s in regulating PER provide new insights into the cellular mechanisms governing circadian rhythms.

Indexed as

Circadian RhythmDrosophila melanogasterDrosophila ProteinsHSP70 Heat-Shock ProteinsPeriod Circadian ProteinsAnimalsMutationProtein BindingDrosophila ProteinsHSP70 Heat-Shock ProteinsPeriod Circadian ProteinsPER protein, Drosophilatim protein, DrosophilaCircadian rhythmCondensation formationHsp70Period

Identifiers

PMID41821096
PMCPMC13093966

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.