Evidence map›Paper›PMID 41821062›Full record

ReviewJournal of cannabis research2026

Sanitation of medical cannabis flowers (Cannabis sativa L., flos): comparing current technologies and non-thermal plasma novelties from safety and quality perspectives.

Samantha Nestel, Claas Hedtfeld, Ulrike Spilker, Jörg Ehlbeck, Sebastian Guenther, Uta Schnabel

Abstract readReview
In one paragraph

Review in Journal of cannabis research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Samantha Nestel *Leibniz Institute for Plasma Science and Technology e.V. (INP), Felix-Hausdorff-Str. 2, Greifswald, 17489, Germany.
Claas Hedtfeld *HerbaMedica GmbH, Fanny-Zobel Str. 9, Berlin, 12435, Germany.
Ulrike SpilkerLeibniz Institute for Plasma Science and Technology e.V. (INP), Felix-Hausdorff-Str. 2, Greifswald, 17489, Germany.
Jörg EhlbeckLeibniz Institute for Plasma Science and Technology e.V. (INP), Felix-Hausdorff-Str. 2, Greifswald, 17489, Germany.
Sebastian GuentherInstitute of Pharmacy, Universität Greifswald, Friedrich-Ludwig-Jahn-Straße 17, Greifswald, 17489, Germany.
Uta SchnabelLeibniz Institute for Plasma Science and Technology e.V. (INP), Felix-Hausdorff-Str. 2, Greifswald, 17489, Germany. uta.schnabel@inp-greifswald.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of cannabis in medicine has rich historical roots spanning thousands of years before stigmatism surrounding the narcotic use of this plant led to strict regulations on its use. Recently, medicinal and recreational cannabis use has experienced a resurgence in many regions of the world, receiving attention from society and policy as legalization increases availability and necessity of greater mindfulness. Research on cannabis is gaining more traction to better inform the regulations needed to ensure the safe and effective usage of this drug. Owing to cannabis being a natural plant product, there are contamination risks even when it is produced under good manufacturing practices (GMPs), which can pose a health risk to consumers. Several pathogenic bacteria and fungi have been found on cannabis, either causing disease in the plant or causing health issues in people who consume the product. The literature on the microbiological safety of cannabis focuses on identifying the species that exist on the plant and the efficacy of sanitation methods currently used in the food industry for the decontamination of cannabis. Specifically, irradiation methods such as gamma irradiation and electron beams have been applied to effectively lower the microbial load on cannabis. However, these irradiation methods face pushbacks due to cost barriers, regulatory issues, and customer disapproval for irradiated products. Innovative gaseous and non-thermal plasma methods are beginning to gain attention because of their preliminary results in effectively decontaminating food products. Indirect non-thermal plasma methods such as ozone and plasma-processed air present new, possibly better, sanitation options for the complex flower structure of cannabis while maintaining its quality. This review discusses the historical importance of cannabis usage and the need to mitigate microbial contamination while considering the current methods used to sanitize cannabis. Finally, we present innovative gaseous and non-thermal plasma methods that are currently being integrated or are under research for cannabis sanitization to improve the safety and future regulatory aspects of cannabis processing.

Indexed as

Electron beamGamma irradiationMedical plant safetyOzonePlasma-processed airUV-C

Identifiers

PMID41821062
PMCPMC13064095

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.